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Assessment of the topical use of lidocaine or bupivacaine on surgical wound healing in dogs

Grant number: 15/24955-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2016
Effective date (End): April 30, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Bruno Watanabe Minto
Grantee:Laura Zanato
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Wound healing is a complex and multifaceted process that involves several factors, including chemical communication among cells and among the extracellular matrix. Substances applied within or around wounds are potentially capable of interfering with the healing process, and that includes local anesthetics. This study proposes to assess if lidocaine or bupivacaine applied locally interfere with the surgical wound healing in dogs. Will be used 30 animals of the canine specie, healthy, non-castrated without limitation due to race, gender, age and weight, divided into 3 groups. These will come from a castration project for population control. During surgery, one skin lesion will be made using a 1cm diameter punch. In the dogs of group 1, 0.1mL of lidocaine with no vasoconstrictor will be instilled; in group 2, will be instilled 0.1mL of bupivacaine and in group 3, 0,1mL of 0.9% saline solution (control). The wounds will be sutured and assessed macroscopically after 1, 3, 10 days. At the end of that period, it will be made an incisional biopsy of the lesions with 2mm of margin of the intact skin and the tissue will be sent for histopathological evaluation.