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Comparative genome analysis of Streptococcus suis strains isolated from swine in Brazil

Grant number: 15/26159-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2016
Effective date (End): September 30, 2019
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Andrea Micke Moreno
Grantee:Carlos Emilio Cabrera Matajira
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Streptococcus suis is an important pathogen in swine production systems in the world. Clinical signs of infection for this agent are variable and can be observed meningitis, arthritis, polyserositis, pneumonia, urinary tract infection and abortion. In recent years, with the growing of pigs intensive production systems, the occurrence of outbreaks of infection by S. suis increased. The high number of carriers of S. suis in animals at slaughter also increases the risk of infection to humans involved in the production chain, as well as to the people handling the meat "in natura". The infection in humans has been described in several countries as a cause of meningitis, pneumonia, endocarditis, sepsis and even death. This project aims the characterization of 215 isolates of S. suis that caused outbreaks in pig farms from different states of the country. This characterization will include the identification of the most prevalent serotypes, the determination of the resistance profile and the changes in this in the last 12 years, evaluation of the strains by PFGE and sequencing of the genome of a group of selected strains. From the sequencing of genomes will be determined the type sequences (STs) that are taking place in the country, genes conferring resistance to antibiotics and newly described virulence genes. These data will serve as a basis for future studies in the country involving the control of the disease in swine and even research involving the occurrence of this agent in humans or other animal species.

Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, MIRELA C. V.; CAMARGO, BEATRIZ Q.; CUNHA, MARCOS P. V.; SAIDENBERG, ANDRE BECKER; TEIXEIRA, RODRIGO H. F.; MATAJIRA, CARLOS E. C.; MORENO, LUISA Z.; GOMES, VASCO T. M.; CHRIST, ANA P. G.; BARBOSA, MIKAELA R. F.; SATO, MARIA I. Z.; MORENO, ANDREA M.; KNOBL, TEREZINHA. Free-Ranging Synanthropic Birds (Ardea alba and Columba livia domestica) as Carriers of Salmonella spp. and Diarrheagenic Escherichia coli in the Vicinity of an Urban Zoo. VECTOR-BORNE AND ZOONOTIC DISEASES, v. 18, n. 1, p. 65-69, JAN 2018. Web of Science Citations: 0.
MORENO, LUISA Z.; MATAJIRA, CARLOS E. C.; POOR, ANDRE P.; MESQUITA, RENAN E.; GOMES, VASCO T. M.; SILVA, ANA PAULA S.; AMIGO, CRISTINA R.; CHRIST, ANA PAULA G.; BARBOSA, MIKAELA R. F.; SATO, MARIA INES Z.; MORENO, ANDREA M. Identification through MALDI-TOF mass spectrometry and antimicrobial susceptibility profiling of bacterial pathogens isolated from sow urinary tract infection. VETERINARY QUARTERLY, v. 38, n. 1, p. 1-8, DEC 7 2017. Web of Science Citations: 2.
POOR, ANDRE P.; MORENO, LUISA Z.; MATAJIRA, CARLOS E. C.; PARRA, BEATRIZ M.; GOMES, VASCO T. M.; SILVA, ANA PAULA S.; DUTRA, MAURICIO C.; CHRIST, ANA PAULA G.; BARBOSA, MIKAELA R. F.; SATO, MARIA INES Z.; MORENO, ANDREA M. Characterization of Corynebacterium diphtheriae, C. confusum and C-amycolatum isolated from sows with genitourinary infection. Veterinary Microbiology, v. 207, p. 149-152, AUG 2017. Web of Science Citations: 2.
MORENO, LUISA Z.; MATAJIRA, CARLOS E. C.; DA COSTA, BARBARA L. P.; FERREIRA, THAIS S. P.; SILVA, GIVAGO F. R.; DUTRA, MAURICIO C.; GOMES, VASCO T. M.; SILVA, ANA PAULA S.; CHRIST, ANA PAULA G.; SATO, MARIA INES Z.; MORENO, ANDREA M. Characterization of porcine Trueperella pyogenes by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), molecular typing and antimicrobial susceptibility profiling in Sao Paulo State. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, v. 51, p. 49-53, APR 2017. Web of Science Citations: 0.
XAVIER OLIVEIRA, MARIA GABRIELA; NOGUEIRA PRESSINOTTI, LEANDRO; SPINOLA CARVALHO, GIOVANE; VILELA OLIVEIRA, MIRELA CAROLINE; MORENO, LUISA ZANOLLI; CABRERA MATAJIRA, CARLOS EMILIO; SPINOLA BERGAMO, ALESSANDRO; MANUEL ALEIXO, VICTOR; CAIXETA VEIGA, ALEXANDRE; DE SOUZA CORSINO, ELVIS; GUARNIERI CHRIST, ANA PAULA; ZANOLLI SATO, MARIA INES; MORENO, ANDREA MICKE; KNOBL, TEREZINHA. Arcobacter spp. in fecal samples from Brazilian farmed caimans (Caiman yacare, Daudin 1802). TROPICAL ANIMAL HEALTH AND PRODUCTION, v. 49, n. 4, p. 777-782, APR 2017. Web of Science Citations: 0.
MATAJIRA, CARLOS E. C.; MORENO, LUISA Z.; GOMES, VASCO T. M.; SILVA, ANA PAULA S.; MESQUITA, RENAN E.; DOTO, DANIELA S.; CALDERARO, FRANCO F.; DE SOUZA, FERNANDO N.; CHRIST, ANA PAULA G.; SATO, MARIA INES Z.; MORENO, ANDREA M. Evaluation of protein spectra cluster analysis for Streptococcus spp. identification from various swine clinical samples. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, v. 29, n. 2, p. 245-249, MAR 2017. Web of Science Citations: 1.
MATAJIRA, CARLOS E. C.; MORENO, LUISA Z.; GOMES, VASCO T. M.; SILVA, ANA PAULA S.; MESQUITA, RENAN E.; AMIGO, CRISTINA R.; CHRIST, ANA PAULA G.; SATO, MARIA INES Z.; MORENO, ANDREA M. Molecular and antimicrobial susceptibility characterization of Globicatella sulfidifaciens isolated from sow's urinary tract infection. VETERINARY QUARTERLY, v. 37, n. 1, p. 48-51, 2017. Web of Science Citations: 0.
MORENO, LUISA Z.; DA COSTA, BARBARA L. P.; MATAJIRA, CARLOS E. C.; GOMES, VASCO T. M.; MESQUITA, RENAN E.; SILVA, ANA PAULA S.; MORENO, ANDREA M. Molecular and antimicrobial susceptibility profiling of Streptococcus dysgalactiae isolated from swine. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 86, n. 2, p. 178-180, OCT 2016. Web of Science Citations: 4.
MORENO, LUISA Z.; MATAJIRA, CARLOS E. C.; GOMES, VASCO T. M.; SILVA, ANA PAULA S.; MESQUITA, RENAN E.; CHRIST, ANA PAULA G.; SATO, MARIA INES Z.; MORENO, ANDREA M. Molecular and antimicrobial susceptibility profiling of atypical Streptococcus species from porcine clinical specimens. INFECTION GENETICS AND EVOLUTION, v. 44, p. 376-381, OCT 2016. Web of Science Citations: 2.
FRANCO F. CALDERARO; LUISA Z. MORENO; DANIELA S. DOTO; CARLOS E.C. MATAJIRA; VASCO T.M. GOMES; THAIS S.P. FERREIRA; RENAN E. MESQUITA; ANDREA M. MORENO. Characterization of Streptococcus suis through serotyping, SE-AFLP and virulence profile. Pesquisa Veterinária Brasileira, v. 36, n. 8, p. 701-704, Ago. 2016. Web of Science Citations: 0.
LUISA Z MORENO; MAURICIO C DUTRA; MARINA MORENO; THAIS SP FERREIRA; GIVAGO FR DA SILVA; CARLOS EC MATAJIRA; ANA PAULA S SILVA; ANDREA M MORENO. Vancomycin-intermediate livestock-associated methicillin-resistant Staphylococcus aureus ST398/t9538 from swine in Brazil. Memórias do Instituto Oswaldo Cruz, v. 111, n. 10, p. 659-661, Out. 2016. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.