Polimeric microparticles containing ascorbic acid and nicotinamide for dermal aplicattion

• Grant number: 15/19097-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2016
• Effective date (End): May 31, 2018
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marcos Antonio Corrêa
• Grantee: Leonardo Delello Di Filippo
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 16/20957-6 - Obtention and physicochemical characterization of polimeric microparticles containing ascorbic acid and nicotinamide., BE.EP.IC

Abstract

Vitamins are widely found in the plant kingdom, such as in plants and fruits. Ascorbic acid (AA) is one of these compounds and has a powerful antioxidant activity, in addition to functioning as a skin whitener, fighting free radicals and hyper-pigmentation of the skin. Another important representative compound is nicotinamide (Vitamin B3 or niacinamide), often used in cosmetics to be a precursor of endogenous macromolecules which possess outstanding antioxidant activity, and induces collagen production and prevents premature aging of the skin. Thus, the use of these compounds in emulsions is very common, due to the ease of use of the final product as well as the pleasant sensory promoted. In order to overcome the skin barrier and decrease the instability of these two compounds, micro and nanostructured systems have been developed to facilitate the delivery of the active, making them available to the tissue for a longer period of time, without causing damage and toxicity. The objective of this work is to obtain biodegradable chitosan microparticles containing ascorbic acid and nicotinamide for dermal application. Thus, the microparticles will be obtained by spray drying and physico-chemically characterized by scanning electron microscopy and spectroscopy in the infrared. Then the microparticles are incorporated into an emulsion.