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Mass spectometry based proteomic in oral squamous cell carcinoma in young patients

Grant number: 16/03248-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2016
Effective date (End): October 31, 2019
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Luiz Paulo Kowalski
Grantee:Marisol Miranda Galvis
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated scholarship(s):17/16347-0 - Functional analysis of HPV-related proteins in oral squamous cell carcinoma, BE.EP.DR


Introduction: Oral Squamous Cell Carcinoma (OSCC) is the fifth malignant neoplasia most common worldwide and affects mostly men between the fifth and sixth decade of life. However, a higher occurrence among young people has recently been reported in different countries of the world, and the clinical and biological behavior of these tumors is still a matter of discussion. Aim: To compare the profile of proteome of OSCC in young patients HPV positive with tissue samples control of patients with the same diagnosis, age and HPV negative. Materials and methods: Will be conducted a study of cases control, experimental analytical, retrospective, of longitudinal cut; to compare the clinicopathological features and mass spectrometry based proteomic and microdissection laser of young patients HPV positive HPV and negative. Expected results: It is expected to identify differences in the molecular pathogenesis of young patients HPV positive and negative, with the propose to obtain new scientific evidence to allow a better understanding of the clinical and biological behavior of OSCC in this group of patients. Enabling future clinical applications to improve the survival rate of affected patients.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GALVIS, MARISOL MIRANDA; BORGES, GABRIEL ALVARES; DE OLIVEIRA, THIAGO BUENO; DE TOLEDO, ISABELA PORTO; CASTILHO, ROGERIO MORAES; SILVA GUERRA, ELIETE NEVES; KOWALSKI, LUIZ PAULO; SQUARIZE, CRISTIANE HELENA. Immunotherapy improves efficacy and safety of patients with HPV positive and negative head and neck cancer: A systematic review and meta-analysis. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, v. 150, JUN 2020. Web of Science Citations: 0.

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