Production of porous material based on calcium aluminate cement my means of replica

• Grant number: 15/22907-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2016
• End date: April 30, 2017
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: Ivone Regina de Oliveira
• Grantee: Larissa dos Santos Reis
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil

Abstract

Calcium aluminate cement (CAC) shows advantages in the physical and mechanical properties, bioactivity when exposed to simulated body fluid solution, and as a barrier against physical and chemical microleakage. Furthermore, through developing the project "Systematic physico-chemical study on cement material for its application as biomaterial," it was possible to determine the influence of additives on its hydration reaction, pH in biological fluid solution, workability/setting time, bioactivity, injectability, and radiopacity. The present study aims to produce biomaterial based on CAC to meet the recommendations of the report of the Prospective Study in Advanced Materials for Applications in Medical-Dental Health to develop materials to be used in the production of scaffolds for tissue engineering. The engineering of tissue for cartilage and bone depends on a biomaterial that serves as a scaffold for cell culturing and development of new tissue. In this area, compatibility between the mechanical and biological properties has not yet been fully achieved. Thus, in this work polymeric sponges will be selected to produce porous biomaterial based on calcium aluminate cement. Furthermore other compounds will be incorporated into the CAC to increase the mechanical strength and biocompatibility with biological system.