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Group II glutamatergic metabotropic receptors role in lateral hypothalamus and perifornicial area (LH/PFA) in daily variations control of ventilatory responses promoted by central chemoreflex activation

Grant number: 16/05174-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2016
Effective date (End): December 31, 2016
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Mirela Barros Dias
Grantee:Laísa Taís Cabral Rodrigues Xavier
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:13/04216-8 - Neural mechanisms involved in the diurnal variation of the central chemoreflex control, AP.JP


Introduction: Evidence suggests the existence of daily variations of the control of the hypercapnic chemoreflex, and has been assigned to orexinergic neurons in the Lateral Hypothalamus and Perifornicial Area (LH / PFA) the role of mediator of the circadian variations in central chemosensitive function, but the mechanisms involved are not well known. Recent results from our group suggest that metabotropic glutamate receptors in the LH/PFA perform an inhibitory modulation of hypercapnic ventilatory response during wakefulness but not during sleep, but it is not known the subtype of metabotropic receptors involved in this effect. Objective: The main purpose of this project is to investigate the possible role of glutamatergic neurotransmission via metabotropic receptors of group II in the LH/PFA in the modulation of ventilatory response to hypercapnia in rats during wakefulness and sleep, in the dark and the light period of the light/dark cycle. Methods: To this end, unilateral injections of LY 341495 (glutamatergic metabotropic antagonist group II) will be performed into the LH/PFA of male Wistar rats, and the pulmonary ventilation will be evaluated in a plethysmography system. It will be studied the effects of this approach in the ventilation in air and 7% CO2, during sleep and wakefulness, in both the light and the dark period. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CABRAL RODRIGUES, LAISA TAIS; DA SILVA, ELIANDRA NUNES; HORTA-JUNIOR, JOSE DE ANCHIETA C.; GARGAGLIONI, LUCIANE H.; DIAS, MIRELA B.. Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO2 chemoreflex. Respiratory Physiology & Neurobiology, v. 260, p. 122-130, . (14/17862-8, 13/04216-8, 16/05174-5)

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