Optimization of the solvent mixture for extraction of phenolic compounds with antioxidant and antiproliferative activities from Byrsonima basiloba Juss. leaves by applying the i-optimal design

• Grant number: 15/24919-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2016
• End date: April 30, 2017
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal Investigator: Catarina dos Santos
• Grantee: Thais Cândido Roberto
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

Phenolic compounds and flavonoids have antioxidant activity which usually has been related to the prevention of diseases such as cancer, diabetes, arthritis and anti- inflammatory processes. Plants of Byrsonima species, which belong to B. basiloba, are recognized for their antibacterial, antifungal, antimutagenic activities, among others. In order to obtain a higher content of phenols and/or flavonoids and with the greatest possible antioxidant activity, it will be done an i- optimal design for choosing the best ratio of solvent (water, methanol and ethanol) from the leaves of B . basiloba.