Effect of É-3 polyunsaturated fatty acids plus low dose of aspirin daily supplementation as adjunctive to full-mouth ultrasonic debridement for the treatment of chronic periodontitis in type 2 diabetic patients. Superiority randomized clinical trial

• Grant number: 16/02234-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): June 01, 2016
• Effective date (End): May 31, 2019
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Mauro Pedrine Santamaria
• Grantee: Nidia Cristina Castro dos Santos
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
• Associated scholarship(s): 17/21136-9 - Immunological actions of daily supplementation of omega-3 polyunsaturated fatty acids plus low-dose aspirin as an adjunct to periodontal debridement for the treatment of chronic periodontitis in patients with type 2 diabetes, BE.EP.DR

Abstract

Diabetes mellitus (DM) has become a global epidemic. Its complications can have a significant impact on quality of life, longevity, and costs in public health. The World Health Organization (WHO) estimates that by 2030, 439 million people will suffer from diabetes, around 10% of the world adult population (WHO, 2011). In Brazil, the Brazilian Society of Diabetes estimates that 12 million people have the disease, which represents a prevalence of approximately 7%. Periodontal Diseases are considered the sixth complication of DM. This close relationship between both diseases is characterized by mutual influence. Thus, an appropriate control of periodontal disease may facilitate the DM control, improving quality of life on diabetes patients. Besides that, the presence of DM might impair prognosis of diverse dental treatments due to its inflammatory nature, negative influence on wound healing, on bone biology, and the establishment of infections. Recently, daily supplementation with omega-3 polyunsaturated fatty acids and aspirin has been proposed as adjunct therapy to the treatment of chronic periodontitis, showing good clinical and metabolic results in normoglycemic patients. Therefore, the aim of this study is to investigate the effectiveness of daily supplementation with omega-3 polyunsaturated fatty acids and aspirin as adjunct therapy to full-mouth ultrasonic periodontal debridement for the treatment of chronic periodontitis in type 2 diabetic patients through a randomized superiority clinical trial.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTRO DOS SANTOS, NIDIA C.; ANDERE, NAIRA M. R. B.; ARAUJO, CASSIA F.; DE MARCO, ANDREA C.; KANTARCI, ALPDOGAN; VAN DYKE, THOMAS E.; SANTAMARIA, MAURO P.. Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial. Journal of Periodontology, v. 91, n. 10, JUN 2020. (16/02234-7, 17/21136-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Nidia Cristina Castro dos. Clinical and immunological effects of omega-3 polyunsaturated fatty acids and low-dose aspirin as adjuncts to periodontal debridement in patients with type 2 diabetes: randomized clinical trial. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Ciência e Tecnologia. São José dos Campos São José dos Campos.