Advanced search
Start date

Effect of É-3 polyunsaturated fatty acids plus low dose of aspirin daily supplementation as adjunctive to full-mouth ultrasonic debridement for the treatment of chronic periodontitis in type 2 diabetic patients. Superiority randomized clinical trial

Grant number: 16/02234-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2016
Effective date (End): May 31, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Mauro Pedrine Santamaria
Grantee:Nidia Cristina Castro dos Santos
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
Associated scholarship(s):17/21136-9 - Immunological actions of daily supplementation of omega-3 polyunsaturated fatty acids plus low-dose aspirin as an adjunct to periodontal debridement for the treatment of chronic periodontitis in patients with type 2 diabetes, BE.EP.DR


Diabetes mellitus (DM) has become a global epidemic. Its complications can have a significant impact on quality of life, longevity, and costs in public health. The World Health Organization (WHO) estimates that by 2030, 439 million people will suffer from diabetes, around 10% of the world adult population (WHO, 2011). In Brazil, the Brazilian Society of Diabetes estimates that 12 million people have the disease, which represents a prevalence of approximately 7%. Periodontal Diseases are considered the sixth complication of DM. This close relationship between both diseases is characterized by mutual influence. Thus, an appropriate control of periodontal disease may facilitate the DM control, improving quality of life on diabetes patients. Besides that, the presence of DM might impair prognosis of diverse dental treatments due to its inflammatory nature, negative influence on wound healing, on bone biology, and the establishment of infections. Recently, daily supplementation with omega-3 polyunsaturated fatty acids and aspirin has been proposed as adjunct therapy to the treatment of chronic periodontitis, showing good clinical and metabolic results in normoglycemic patients. Therefore, the aim of this study is to investigate the effectiveness of daily supplementation with omega-3 polyunsaturated fatty acids and aspirin as adjunct therapy to full-mouth ultrasonic periodontal debridement for the treatment of chronic periodontitis in type 2 diabetic patients through a randomized superiority clinical trial.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTRO DOS SANTOS, NIDIA C.; ANDERE, NAIRA M. R. B.; ARAUJO, CASSIA F.; DE MARCO, ANDREA C.; KANTARCI, ALPDOGAN; VAN DYKE, THOMAS E.; SANTAMARIA, MAURO P. Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial. Journal of Periodontology, v. 91, n. 10 JUN 2020. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Nidia Cristina Castro dos. Efeitos clínicos e imunológicos de ácidos graxos poli-insaturados de ômega-3 e aspirina em baixa dosagem como adjuvantes ao debridamento periodontal em pacientes com diabetes tipo 2 : estudo clínico randomizado. 2019. 70 f. Doctoral Thesis - Universidade Estadual Paulista "Julio de Mesquita Filho" Instituto de Ciência e Tecnologia (Campus de São José dos Campos)..

Please report errors in scientific publications list by writing to: