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Research on hantavirus and other viruses in wild small mammals and their ectoparasites

Grant number: 16/02568-2
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2016
Effective date (End): March 31, 2019
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Luiz Tadeu Moraes Figueiredo
Grantee:Gilberto Sabino dos Santos Junior
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/02438-6 - Studies with Bunyaviridae that produce human disease, AP.TEM

Abstract

A complex mix of predisposing factors in our modern world has created new opportunities for the emergence of infectious diseases in animals and humans alike. This is largely related to globalization and environmental changes such as degradation, which increases the changing nature of contacts between animals and humans. Viruses are the most abundant biological entities on the planet, and viruses that have their origin in animal world cause most of these emerging diseases in humans. Small mammals such as small rodents, marsupials, and especially bats are important reservoirs of viruses. During the period from June 2008 to April 2014 we captured 1440 wild small mammals in the north-eastern São Paulo region, and North of Minas Gerais state. Samples such as excreta (faeces and urine), blood, saliva, tissues of organs: heart, lung, spleen, liver and kidneys were collected and preserved in liquid nitrogen, and finally stored at ultra freezers - 80°C with a fruitful end: the viral meta-genomics. We also intend to conduct captures of small mammals for one year in all regions of Brazil to increase the samples' number. All ecological data of small mammals are and will be recorded in a database, as well as environmental data that will help on viral ecology analysis. Therefore, it is proposed here to detect emerging viruses, in particular hantavirus, arenavirus, and influenza virus by viral meta-genomic techniques among small wild mammals and their ectoparasites in order to understand the viral ecology: (i) viral diversity, (ii) community structure from the natural reservoirs, and (iii) philogeography; and discover new viral species that might help elucidate evolutionary gaps. Thus, we intend to understand the dynamics of infections in nature and predict, perhaps, future threats to animals and humans health. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOTTA MAIA, FELIPE GONCALVES; DE SOUZA, WILLIAM MARCIEL; SABINO-SANTOS, JR., GILBERTO; FUMAGALLI, MARCILIO JORGE; MODHA, SEJAL; MURCIA, PABLO RAMIRO; MORAES FIGUEIREDO, LUIZ TADEU. A novel polyomavirus in sigmodontine rodents from So Paulo State, Brazil. ARCHIVES OF VIROLOGY, v. 163, n. 10, p. 2913-2915, . (12/24150-9, 17/13981-0, 16/01414-1, 13/14929-1, 16/02568-2, 11/06810-9, 08/06411-4, 11/22663-6, 15/05778-5)
DE SOUZA, WILLIAM MARCIEL; DENNIS, TRISTAN; FUMAGALLI, MARCILIO JORGE; ARAUJO, JANSEN; SABINO-SANTOS, JR., GILBERTO; MOTTA MAIA, FELIPE GONCALVES; ACRANI, GUSTAVO OLSZANSKI; TORRES CARRASCO, ADRIANO DE OLIVEIRA; ROMEIRO, MARILIA FARIGNOLI; MODHA, SEJAL; et al. Novel Parvoviruses from Wild and Domestic Animals in Brazil Provide New Insights into Parvovirus Distribution and Diversity. Viruses-Basel, v. 10, n. 4, . (09/05994-9, 15/05778-5, 12/24150-9, 11/13821-7, 11/06810-9, 17/13981-0, 11/22663-6, 16/01414-1, 13/14929-1, 16/02568-2, 14/20851-8, 08/06411-4)
SABINO-SANTOS, JR., GILBERTO; MOTTA MAIA, FELIPE GONCALVES; MARTINS, RONALDO BRAGANCA; GAGLIARDI, TALITA BIANCA; DE SOUZA, WILLIAM MARCIEL; MUYLAERT, RENATA LARA; DE SOUZA LUNA, LUCIANO KLEBER; MELO, DANILO MACHADO; CARDOSO, RICARDO DE SOUZA; BARBOSA, NATALIA DA SILVA; et al. Natural infection of Neotropical bats with hantavirus in Brazil. SCIENTIFIC REPORTS, v. 8, . (12/24150-9, 11/06810-9, 11/19897-5, 11/22663-6, 16/02568-2, 12/03700-0, 14/02438-6, 15/05354-0, 15/06142-7, 13/06380-0, 12/04096-0)
DE SOUZA, WILLIAM MARCIEL; ROMEIRO, MARILIA FARIGNOLI; SABINO-SANTOS, JR., GILBERTO; MOTTA MAIA, FELIPE GONCALVES; FUMAGALLI, MARCILIO JORGE; MODHA, SEJAL; TEIXEIRA NUNES, MARCIO ROBERTO; MURCIA, PABLO RAMIRO; MORAES FIGUEIREDO, LUIZ TADEU. Novel orthohepeviruses in wild rodents from Sao Paulo State, Brazil. VIROLOGY, v. 519, p. 12-16, . (15/05778-5, 12/24150-9, 11/06810-9, 17/13981-0, 11/22663-6, 16/01414-1, 13/14929-1, 16/02568-2, 14/20851-8, 08/06411-4)
DE SOUZA, WILLIAM MARCIEL; FUMAGALLI, MARCILIO JORGE; SABINO-SANTOS, JR., GILBERTO; MOTTA MAIA, FELIPE GONCALVES; MODHA, SEJAL; TEIXEIRA NUNES, MARCIO ROBERTO; MURCIA, PABLO RAMIRO; MORAES FIGUEIREDO, LUIZ TADEU. A Novel Hepacivirus in Wild Rodents from South America. Viruses-Basel, v. 11, n. 3, . (12/24150-9, 17/13981-0, 16/01414-1, 13/14929-1, 16/02568-2, 11/06810-9, 08/06411-4, 11/22663-6, 15/05778-5)
SABINO-SANTOS JR, GILBERTO; FERREIRA, FRANCIMEIRE FERNANDES; FERREIRA DA SILVA, DAVID JOSE; MACHADO, DANILO MELO; DA SILVA, SERGIO GOMES; SAO BERNARDO, CHRISTINE STEINER; DOS SANTOS FILHO, MANOEL; LEVI, TAAL; MORAES FIGUEIREDO, LUIZ TADEU; PERES, CARLOS A.; et al. Hantavirus antibodies among phyllostomid bats from the arc of deforestation in Southern Amazonia, Brazil. TRANSBOUNDARY AND EMERGING DISEASES, v. 67, n. 3, . (14/02438-6, 16/02568-2)
MUYLAERT, RENATA L.; SABINO-SANTOS JR, GILBERTO; PRIST, PAULA R.; OSHIMA, JULIA E. F.; NIEBUHR, BERNARDO BRANDAO; SOBRAL-SOUZA, THADEU; DE OLIVEIRA, STEFAN VILGES; BOVENDORP, RICARDO SIQUEIRA; MARSHALL, JONATHAN C.; HAYMAN, DAVID T. S.; et al. Spatiotemporal Dynamics of Hantavirus Cardiopulmonary Syndrome Transmission Risk in Brazil. Viruses-Basel, v. 11, n. 11, . (13/50421-2, 15/17739-4, 16/02568-2, 17/11666-0, 17/21816-0, 13/25441-0)
DE SOUZA, WILLIAM MARCIEL; FUMAGALLI, MARCILIO JORGE; DE ARAUJO, JANSEN; SABINO-SANTOS, JR., GILBERTO; MOTTA MAIA, FELIPE GONSALVES; ROMEIRO, MARILIA FARIGNOLI; MODHA, SEJAL; NARDI, MARCELLO SCHIAVO; QUEIROZ, LUZIA HELENA; DURIGON, EDISON LUIZ; et al. Discovery of novel anelloviruses in small mammals expands the host range and diversity of the Anelloviridae. VIROLOGY, v. 514, p. 9-17, . (15/05778-5, 12/24150-9, 11/06810-9, 13/14929-1, 11/22663-6, 16/01414-1, 16/02568-2, 14/20851-8, 08/06411-4)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.