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The effect of cryotherapy in pain control, function and quality of life in individuals with knew osteoarthritis: randomized clinical trial

Grant number: 15/21422-6
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): July 01, 2016
Effective date (End): December 28, 2020
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Tania de Fatima Salvini
Grantee:Lucas Ogura Dantas
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):18/07462-3 - A novel smartphone application integrated with wearable devices for knee osteoarthritis clinical trials: a feasibility study, BE.EP.DD


Introduction: osteoarthritis (OA) is a major cause of disability in adults and seniors; it decreases quality of life, and is responsible for one-eighth of all restriction of daily living activities in patients with it. Among the weight-bearing joints, the knee is the most affected by OA. Knee Osteoarthritis (KOA) causes symptoms such as joint stiffness, pain, physical dysfunction, and this leads to a considerable impact in individuals’ quality of life. Currently, different treatment options are available for KOA. A combination of non-pharmacological treatments, which include patient education, exercise, lifestyle changes and physiotherapy, associated with pharmacological treatments are the best option. Cryotherapy, a non-pharmacological intervention widely used in muscle skeletal injuries to control pain symptoms, has also been used in KOA. However, there is still a lack of scientific evidence regarding its effects in KOA. Few studies have evaluated the analgesic effects and outcomes on quality of life of patients with KOA, after the use of cryotherapy isolated. In addition, systematic review studies point to a weak scientific evidence for the use of cryotherapy in KOA due to deficiencies in methodological design of most studies. Thus, the results of a randomized controlled clinical trial about the effects of cryotherapy in KOA might contribute to a better scientific basis for the role of cryotherapy in KOA. Objectives: to assess the effect of cryotherapy (ice bag shredded) around the knee of individuals with KOA in the pain control, function and quality of life of these individuals. Methodology: this is a randomized controlled clinical trial, double-blinded. Will participate in the study 46 patients with KOA, diagnosed with clinical and radiographic criteria of the American College of Rheumatology, of both sexes, aged between 40 and 65 years. The total number of subjects will be divided randomly into two groups of 23 subjects each. During four consecutive days, for a period of 20 min, each group will receive one type of intervention around the knee with OA: the cryotherapy group will receive an application of ice bags with compression and the placebo group will receive an application of sand bags with compression, the weight and volume of the sand bags will be similar to that used in cryotherapy. Every individual will have the following variables evaluated pre- and post-intervention: pressure pain threshold (algometry), pain index (VAS), physical function questionnaires (WOMAC, KOOS) and physical activity (IPAQ). Two physical function tests will also be carried out: the 30s sitting and standing chair and the Timed Up and Go (TUG). Thermographic images will also be obtained for further temperature analysis of the knee with OA. Data analysis: the normality of the data will be evaluated and parametric or non-parametric tests could be used. The comparison between the means of the dependent variables will be done. The independent study factors will be cryotherapy versus placebo and the factor of repeated measures pre- versus post-intervention. Possible correlations between the dependent interest variables of the study will also be evaluated. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JORGE, ANA E. S.; DANTAS, LUCAS O.; SERRAO, PAULA R. M. S.; ALBURQUERQUE-SENDIN, FRANCISCO; SALVINI, TANIA F.. Photobiomodulation therapy associated with supervised therapeutic exercises for people with knee osteoarthritis: a randomised controlled trial protocol. BMJ OPEN, v. 10, n. 6, . (17/00062-7, 15/21422-6)
DANTAS, LUCAS OGURA; CARVALHO, CRISTIANO; PRANDO, BEATRIZ CARDINAL; MCALINDON, TIMOTHY E.; DA SILVA SERRAO, PAULA REGINA MENDES. Mobile health technologies for the management of rheumatic diseases: a systematic review of online stores in Brazil. CLINICAL RHEUMATOLOGY, v. 40, n. 7, . (15/21422-6, 17/20057-8)
DANTAS, LUCAS OGURA; JORGE, ANA ELISA SERAFIM; DA SILVA SERRAO, PAULA REGINA MENDES; ABURQUERQUE-SENDIN, FRANCISCO; SALVINI, TANIA DE FATIMA. Cryotherapy associated with tailored land-based exercises for knee osteoarthritis: a protocol for a double-blind sham-controlled randomised trial. BMJ OPEN, v. 10, n. 6, . (17/00062-7, 15/21422-6)
DANTAS, LUCAS OGURA; CARVALHO, CRISTIANO; PENA, CAROLINE; BREDA, CAROLINA CARREIRA; DRIUSSO, PATRICIA; FERREIRA, CRISTINE HOMSI JORGE; BO, KARI. Mobile health technologies for the monitoring of menstrual cycle: A systematic review of online stores in Brazil. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, v. 48, n. 1, . (17/20057-8, 15/21422-6, 20/13066-3)
DANTAS, LUCAS OGURA; CARREIRA MOREIRA, ROBERTA DE FATIMA; NORDE, FLAVIA MAINTINGUER; MENDES SILVA SERRAO, PAULA REGINA; ALBURQUERQUE-SENDIN, FRANCISCO; SALVINI, TANIA FATIMA. The effects of cryotherapy on pain and function in individuals with knee osteoarthritis: a systematic review of randomized controlled trials. CLINICAL REHABILITATION, v. 33, n. 8, p. 1310-1319, . (15/21422-6)
DANTAS, LUCAS OGURA; BREDA, CAROLINA CARREIRA; MENDES DA SILVA SERRAO, PAULA REGINA; ABURQUERQUE-SENDIN, FRANCISCO; SERAFIM JORGE, ANA ELISA; CUNHA, JONATHAN EMANUEL; BARBOSA, GERMANNA MEDEIROS; QUAGLIOTTI DURIGAN, JOAO LUIZ; SALVINI, TANIA DE FATIMA. Short-term cryotherapy did not substantially reduce pain and had unclear effects on physical function and quality of life in people with knee osteoarthritis: a randomised trial. JOURNAL OF PHYSIOTHERAPY, v. 65, n. 4, p. 215-221, . (11/22122-5, 15/21422-6)

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