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Bone healing evaluation in the bone / implant interface in estrogen deficient rats treated with human OPG-Fc or Strontium ranelate . Histometric, immunohistochemistry, biomechanics, computed microtomography and confocal microscopy analysis

Grant number: 15/13712-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2016
Effective date (End): May 31, 2018
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Roberta Okamoto
Grantee:Juliana Zorzi Coléte
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

This study will evaluate the peri-implant bone healing in rats submitted to ovariectomy and treated with strontium ranelate (625mg / kg / day) or OPG-Fc (10 mg / kg / 2 times per week). Eighty rats, 300 g, will be divided into six experimental groups according to the osteoporosis treatment: SHAM / SAL; OVX / SAL; OVX / RE; SHAM / SH; OVX / SH; OVX / OPG-Fc. Each animal will receive two implants on each tibia metaphysis. Euthanasia will be at 42 and 60 days after implants placement. The three-dimensional microtomography will be performed (micro CT), biomechanical (reverse torque) histometric, confocal laser microscopy, analysis of gene expression by real-time PCR, histological and immunohistochemical of proteins that characterize the bone remodeling process (OPG, osteocalcin, RANKL, TRAP) and Wnt pathway. Quantitative data will be submitted to statistical normality and homoscedasticity tests, applied a parametric or nonparametric test. For all data will be regarded 5% significance level.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

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