Advanced search
Start date
Betweenand
Related content

Influence of sexual hormones ín “The ventilatory, thermal ánd central monoamines concentration ín male ánd female rats

Grant number: 16/04276-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2016
Effective date (End): August 31, 2019
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Luciane Helena Gargaglioni Batalhão
Grantee:Danuzia Ambrozio Marques
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):16/21730-5 - LOCATION OF MEMBRANE PROGESTERONE RECEPTOR BETA IN RESPIRATORY NEURONS OF THE BRAINSTEM OF MALES AND FEMALES RATS AND EFFECTS OF HYPOXIA, BE.EP.DR

Abstract

According to the literature there are many differences between genders in the control of ventilation since studies show a sexual dimorphism in abnormalities in the respiratory system of humans as apneas, hypopneas, and breathing oscillations that present an incidence three times higher in men than in women. Sex-specific differences were also observed in control of body temperature (Tb) where women have a higher Tb during menstrual cycle. One possible explanation for this difference between the sexes in the control of Tb and in breathing is precisely linked to differences in sex hormone concentrations, e.g., testosterone, estradiol and progesterone, that exist between males and females. Furthermore, it is known that there are regions in the central nervous system (CNS) that are sexually dimorphic and play an important role in the control of thermogenesis and ventilation such as POA and LC.In CNS regions including LC, Raphe and POA, that have sex-specific differences, it is known that neurotransmitters classified as monoamines: dopamine (DA) and norepinephrine (NE) and serotonin (5-HT) are involved in the control of ventilation and body temperature. Therefore, the goal of our project is to evaluate the influence of the sex hormones on ventilation and body temperature during hypercapnia and hypoxia as well as to quantify the three monoamines listed above in the nuclei of Raphe, POA and LC, of male and female rats using the technique of punch out in these regions and analizing by HPLC-ED .Keywords: CNS, sexual dimorphism, catecholamines, punch, HPLC-ED, plethysmography, hormone replacement, castration, Wistar rats.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GARGAGLIONI, LUCIANE H.; MARQUES, DANUZIA A.; PATRONE, LUIS GUSTAVO A. Sex differences in breathing. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 238, DEC 2019. Web of Science Citations: 0.
MARQUES, DANUZIA A.; DE CARVALHO, DEBORA; DA SILVA, GLAUBER S. F.; SZAWKA, RAPHAEL E.; ANSELMO-FRANCI, JANETE A.; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H. Influence of estrous cycle hormonal fluctuations and gonadal hormones on the ventilatory response to hypoxia in female rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 469, n. 10, p. 1277-1286, OCT 2017. Web of Science Citations: 7.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.