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The influence of gut microbiota on blood pressure

Grant number: 16/10807-7
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): September 26, 2016
Effective date (End): September 25, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Mario Jose Abdalla Saad
Grantee:Carla Grazielle Bueno Silva
Supervisor abroad: Mansour Mohamadzadeh
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Local de pesquisa : University of Florida, Gainesville (UF), United States  
Associated to the scholarship:16/04723-5 - “The influence of gut microbiota ín blood pressure modulation of rodents: “The role of hydrogen sulfide (H2S) ánd short-chain fatty acids, BP.DR

Abstract

Systemic arterial hypertension (SAH) is a major challenge for world publichealth, since it contributes to the mortality and morbidity related to heart failure,ischemic stroke, kidney disease, atherosclerosis and cardiac hypertrophy. It isknown that the pathophysiology of hypertension involves a variety of organs andsystems. Recent research indicates that gut microbiota may also play a critical rolein maintaining the blood pressure (BP).Accordingly, this work aims to analyze the association between hypertensionand gut microbiota in several experimental models, taking into account genetic,environmental and dietary factors that profoundly influence both the gut microbiotaand the BP. This study raises two hypotheses of possible bacterial mechanisms onBP modulation: First, the role of short chain fatty acids (SCFA), which bind to Gprotein­coupled receptor GPR43 and OlfR78 and are related directly and indirectly toblood pressure modulation. The second hypothesis takes into account the bacterialproduction of H2S and its vasodilating effect on the host efferent arteries.