Effects of monosodium glutamate administration in Kiss1 neurons and its correlation with reproductive disorders

• Grant number: 16/03082-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2016
• End date: August 31, 2017
• Field of knowledge: Biological Sciences - Physiology
• Principal Investigator: Renata Frazão
• Grantee: Daniella Gonçalves de Paula
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The hypothalamus-pituitary-gonads axis is responsible for neuroendocrine regulation of reproduction, by the action of GnRH, LH and FSH hormones. Kisspeptin, produced by Kiss1 neurons localized in hypothalamus - more specific in arcuate (Arc) and Anteroventral Periventricular nucleus (AVPV), acts together with GPR54 receptor as a exterior signals processor for reproduction, modulating GnRH pulses. It is well known that the body weight changes affect this signalization and consequently impairs fertility. Literature describes the monosodium glutamate treatment as a protocol to induced obesity due to neuronal destruction of hypothalamic neurons locate at the Arc, been one of the consequent effects reproductive disorders. This project aims to determine if those reproductive disorders occurs due to damage to Kiss1 neurons.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZAMPIERI, THAIS TESSARI; BOHLEN, TABATA MARIZ; SILVEIRA, MARINA AUGUSTO; LANA, LARISSA CAMPISTA; DE PAULA, DANIELLA G.; DONATO, JOSE; FRAZAO, RENATA. Postnatal Overnutrition Induces Changes in Synaptic Transmission to Leptin Receptor-Expressing Neurons in the Arcuate Nucleus of Female Mice. NUTRIENTS, v. 12, n. 8, AUG 2020. (16/03082-6, 17/02983-2, 13/07908-8, 15/14588-5, 15/20198-5)

BOHLEN, TABATA M.; DE PAULA, DANIELLA G.; TEIXEIRA, PRYSCILA D. S.; MANSANO, NAIRA DA SILVA; ALVES, GUILHERME ANDRADE; DONATO JR, JOSE; FRAZAO, RENATA. Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss. CYTOKINE, v. 158, p. 9-pg., 2022-08-17. (15/14588-5, 19/21707-1, 20/01318-8, 13/00801-3, 16/03082-6, 17/22189-9)

PAULA, DANIELLA G. DE; BOHLEN, TABATA M.; ZAMPIERI, THAIS TESSARI; MANSANO, NAIRA S.; VIEIRA, HENRIQUE R.; GUSMAO, DANIELA O.; WASINSKI, FREDERICK; DONATO JR, JOSE; FRAZAO, RENATA. Distinct effects of growth hormone deficiency and disruption of hypothalamic kisspeptin system on reproduction of male mice. Life Sciences, v. 285, NOV 15 2021. (20/01318-8, 16/03082-6, 21/03316-5, 16/20897-3, 15/20198-5, 13/07908-8, 15/14588-5, 17/22189-9)