Advanced search
Start date
Betweenand

Genetic and phylodynamics diversity of emerging and re-emerging arboviruses (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil, 2014-2016

Grant number: 16/08204-2
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2016
Effective date (End): March 31, 2019
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal researcher:Paolo Marinho de Andrade Zanotto
Grantee:Marielton dos Passos Cunha
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Viruses transmitted by arthropods (arboviruses) are responsible for emerging and reemerging infectious diseases in different areas of the world, especially in tropical and subtropical regions. Among these viruses, we could highlight those belonging to the Flaviviridae and Togaviridae families, which may cause clinical manifestations ranging from asymptomatic infection, acute febrile to disease viral haemorrhagic fever and encephalitis. In Brazil, the virus that stand out are the Dengue virus (DENV), Chikungunya virus (CHIKV) and Zika virus (ZIKV), the last two first identified in 2014 and 2015 respectively, causing severe Public Health problems, especially in the Northeast region of Brazil. However, the processes that shape patterns of transmission in urban scales are unknown for these viruses, particularly the impact of factors such as the movement of the human population and urbanization. Elucidating the spread of emerging and reemerging arboviruses in Brazil in time and space is central to understanding of its epidemiology. In this context, this study aims to understand the dynamics of urban spread of emerging and re-emerging arbovirus (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil (states of Sergipe and São Paulo), and identify the demographics and socioeconomic factors associated with the dynamics of viral movement that can provide new opportunities for control and intervention strategies.

News published in Agência FAPESP Newsletter about the scholarship:
Paciente em São Paulo não morreu por reação à vacina da febre amarela, indica estudo 
Matéria(s) publicada(s) na Revista Pesquisa FAPESP sobre a bolsa::
Sangre limpia contra la fiebre amarilla 
Clean blood against yellow fever 
Articles published in other media outlets (1 total):
Biblioteca FMUSP: Sangue limpo contra a febre amarela (26/Sep/2019)

Scientific publications (17)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CUNHA, MARIELTON DOS PASSOS; DUARTE-NETO, AMARO NUNES; POUR, SHAHAB ZAKI; HAJJAR, LUDHMILA ABRAHAO; FRASSETTO, FERNANDO PEREIRA; DOLHNIKOFF, MARISA; DO NASCIMENTO SALDIVA, PAULO HILARIO; DE ANDRADE ZANOTTO, PAOLO MARINHO. Systemic dengue infection associated with a new dengue virus type 2 introduction in Brazil - a case report. BMC INFECTIOUS DISEASES, v. 21, n. 1 APR 1 2021. Web of Science Citations: 0.
DIENG, IDRISSA; DOS PASSOS CUNHA, MARIELTON; DIAGNE, MOUSSA MOISE; SEMBENE, PAPE MBACKE; DE ANDRADE ZANOTTO, PAOLO MARINHO; FAYE, OUSMANE; FAYE, OUMAR; SALL, AMADOU ALPHA. Origin and Spread of the Dengue Virus Type 1, Genotype V in Senegal, 2015-2019. Viruses-Basel, v. 13, n. 1 JAN 2021. Web of Science Citations: 0.
CUNHA, MARIELTON DOS PASSOS; IOSHINO, RAFAELLA SAYURI; COSTA-DA-SILVA, ANDRE LUIS; PETERSEN, VIVIAN; CAPURRO, MARGARETH LARA; ZANOTTO, PAOLO MARINHO DE ANDRADE. A Metagenomic Approach Identified a Novel Phasi Charoen- Like Virus Coinfecting a Chikungunya Virus-Infected Aedes aegypti Mosquito in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 9, n. 31 JUL 2020. Web of Science Citations: 1.
CUNHA, MARIELTON DOS PASSOS; DUARTE-NETO, AMARO NUNES; POUR, SHAHAB ZAKI; ORTIZ-BAEZ, AYDA SUSANA; CERNY, JIRI; DE SOUZA PEREIRA, BARBARA BRITO; BRACONI, CARLA TORRES; HO, YEH-LI; PERONDI, BEATRIZ; SZTAJNBOK, JAQUES; FERREIRA ALVES, VENANCIO AVANCINI; DOLHNIKOFF, MARISA; HOLMES, EDWARD C.; NASCIMENTO SALDIVA, PAULO HILARIO; DE ANDRADE ZANOTTO, PAOLO MARINHO. Origin of the Sao Paulo Yellow Fever epidemic of 2017-2018 revealed through molecular epidemiological analysis of fatal cases. SCIENTIFIC REPORTS, v. 9, DEC 31 2019. Web of Science Citations: 0.
DUARTE-NETO, AMARO N.; CUNHA, MARIELTON DOS P.; MARCILIO, IZABEL; SONG, ALICE T. W.; DE MARTINO, RODRIGO B.; HO, YEH-LI; POUR, SHAHAB Z.; DOLHNIKOFF, MARISA; SALDIVA, PAULO H. N.; DUARTE, MARIA I. S.; TAKAKURA, CLEUSA F.; LIMA, FABIANA R.; TANIGAWA, RYAN Y.; IGLEZIAS, SILVIA D'A; KANAMURA, CRISTINA T.; DOS SANTOS, ANGELA B. G.; PERONDI, BEATRIZ; ZANOTTO, PAOLO M. DE A.; D'ALBUQUERQUE, LUIZ A. C.; ALVES, VENANCIO A. F. Yellow fever and orthotopic liver transplantation: new insights from the autopsy room for an old but re-emerging disease. Histopathology, v. 75, n. 5, p. 638-648, NOV 2019. Web of Science Citations: 5.
DUARTE-NETO, AMARO NUNES; DE ALMEIDA MONTEIRO, RENATA APARECIDA; JOHNSSON, JANAINA; CUNHA, MARIELTON DOS PASSOS; POUR, SHAHAB ZAKI; SARAIVA, AMANDA CARTAGENES; HO, YEH-LI; FERRAZ DA SILVA, LUIZ FERNANDO; MAUAD, THAIS; DE ANDRADE ZANOTTO, PAOLO MARINHO; NASCIMENTO SALDIVA, PAULO HILARIO; SOUZA DE OLIVEIRA, ILKA REGINA; DOLHNIKOFF, MARISA. Ultrasound-guided minimally invasive autopsy as a tool for rapid post-mortem diagnosis in the 2018 Sao Paulo yellow fever epidemic: Correlation with conventional autopsy. PLoS Neglected Tropical Diseases, v. 13, n. 7 JUL 2019. Web of Science Citations: 1.
SOARES-SCHANOSKI, ALESSANDRA; BAPTISTA CRUZ, NATALIA; DE CASTRO-JORGE, LUIZA ANTUNES; HOMEM DE CARVALHO, RENAN VILLANOVA; DOS SANTOS, CLIOMAR ALVES; DA ROS, NANCY; OLIVEIRA, URSULA; COSTA, DANUZA DUARTE; SIMOES DOS SANTOS, CECILIA LUIZA; CUNHA, MARIELTON DOS PASSOS; SARNO OLIVEIRA, MARIA LEONOR; ALVES, JULIANA CARDOSO; DE LUCENA COUTO OCEA, REGINA ADALVA; RIBEIRO, DANIELLE RODRIGUES; AQUIME GONCALVES, ANDRE NICOLAU; GONZALEZ-DIAS, PATRICIA; SUHRBIER, ANDREAS; DE ANDRADE ZANOTTO, PAOLO MARINHO; DE AZEVEDO, INACIO JUNQUEIRA; ZAMBONI, DARIO S.; ALMEIDA, ROQUE PACHECO; HO, PAULO LEE; KALIL, JORGE; NISHIYAMA, MILTON YUTAKA; NAKAYA, HELDER I. Systems analysis of subjects acutely infected with the Chikungunya virus. PLOS PATHOGENS, v. 15, n. 6 JUN 2019. Web of Science Citations: 4.
DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; LIMA, FLAVIA AFONSO; BANDEIRA, CARLA LETICIA; MURILLO, OSCAR; COSTA, DOUGLAS DE SOUSA; MACHADO PEIXOTO, ERIKA PAULA; CUNHA, MARIELTON DOS PASSOS; DE ANDRADE ZANOTTO, PAOLO MARINHO; BEVILACQUA, ESTELA; GRIGOLIN GRISOTTO, MARCOS AUGUSTO; PEDROSO DE LIMA, ANTONIO CARLOS; SINGER, JULIO DA MOTTA; CAMPINO, SUSANA; CLARK, TAANE GREGORY; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon. JAMA NETWORK OPEN, v. 2, n. 5 MAY 2019. Web of Science Citations: 1.
ORTIZ-BAEZ, AYDA SUSANA; CUNHA, MARIELTON DOS PASSOS; VEDOVELLO, DANILA; COLOMBO, TATIANA ELIAS; NOGUEIRA, MAURICIO LACERDA; VILLABONA-ARENAS, CHRISTIAN JULIAN; DE ANDRADE ZANOTTO, PAOLO MARINHO. Origin, tempo, and mode of the spread of DENV-4 Genotype IIB across the state of Sao Paulo, Brazil during the 2012-2013 outbreak. Memórias do Instituto Oswaldo Cruz, v. 114, 2019. Web of Science Citations: 1.
OLIVEIRA, DANIELLE B. L.; DURIGON, GIULIANA S.; MENDES, ERICA A.; LADNER, JASON T.; ANDREATA-SANTOS, ROBERT; ARAUJO, DANIELLE B.; BOTOSSO, VIVIANE F.; PAOLA, NICHOLAS D.; NETO, DANIEL F. L.; CUNHA, MARIELTON P.; BRACONI, CARLA T.; ALVES, RUBENS P. S.; JESUS, MONICA R.; PEREIRA, LENNON R.; MELO, STELLA R.; MESQUITA, FLAVIO S.; SILVEIRA, VANESSA B.; THOMAZELLI, LUCIANO M.; FAVORETTO, SILVANA R.; ALMONFREY, FRANCIANE B.; ABDULKADER, REGINA C. R. M.; GABRILI, JOEL M.; TAMBOURGI, DENISE V.; OLIVEIRA, SERGIO F.; PRIETO, KARLA; WILEY, MICHAEL R.; FERREIRA, LUIS C. S.; SILVA, MARCOS V.; PALACIOS, GUSTAVO F.; ZANOTTO, PAOLO M. A.; DURIGON, EDISON L. Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System. Viruses-Basel, v. 10, n. 11 NOV 2018. Web of Science Citations: 3.
CUNHA, MARIELTON DOS PASSOS; ORTIZ-BAEZ, AYDA SUSANA; DE MELO FREIRE, CAIO CESAR; DE ANDRADE ZANOTTO, PAOLO MARINHO. Codon adaptation biases among sylvatic and urban genotypes of Dengue virus type 2. INFECTION GENETICS AND EVOLUTION, v. 64, p. 207-211, OCT 2018. Web of Science Citations: 1.
DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL DE OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequences of Five Human Respiratory Syncytial Virus Isolates Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 7 FEB 2018. Web of Science Citations: 0.
DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequence of a Human Metapneumovirus Isolate Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 6 FEB 2018. Web of Science Citations: 0.
BARBOSA, CARLA M.; DI PAOLA, NICHOLAS; CUNHA, MARIELTON P.; RODRIGUES-JESUS, MONICA J.; ARAUJO, DANIELLE B.; SILVEIRA, VANESSA B.; LEAL, FABYANO B.; MESQUITA, FLAVIO S.; BOTOSSO, VIVIANE F.; ZANOTTO, PAOLO M. A.; DURIGON, EDISON L.; SILVA, MARCOS V.; OLIVEIRA, DANIELLE B. L. Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil. Emerging Infectious Diseases, v. 24, n. 1, p. 176-178, JAN 2018. Web of Science Citations: 19.
CUNHA, MARIELTON DOS PASSOS; DOS SANTOS, CLIOMAR ALVES; DE LIMA NETO, DANIEL FERREIRA; SCHANOSKI, ALESSANDRA SOARES; POUR, SHAHAB ZAKI; PASSOS, SAULO DUARTE; FEITOSA DE SOUZAE, MERCIA SIMONE; COSTA, DANUZA DUARTE; DE ANDRADE ZANOTTO, PAOLO MARINHO. Outbreak of chikungunya virus in a vulnerable population of Sergipe, Brazil-A molecular and serological survey. Journal of Clinical Virology, v. 97, p. 44-49, DEC 2017. Web of Science Citations: 9.
DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL DE OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 5, n. 49 DEC 2017. Web of Science Citations: 0.
COSTA-DA-SILVA, ANDRE LUIS; IOSHINO, RAFAELLA SAYURI; PETERSEN, VIVIAN; LIMA, ANTONIO FERNANDO; CUNHA, MARIELTON DOS PASSOS; WILEY, MICHAEL R.; LADNER, JASON T.; PRIETO, KARLA; PALACIOS, GUSTAVO; COSTA, DANUZA DUARTE; SUESDEK, LINCOLN; DE ANDRADE ZANOTTO, PAOLO MARINHO; CAPURRO, MARGARETH LARA. First report of naturally infected Aedes aegypti with chikungunya virus genotype ECSA in the Americas. PLoS Neglected Tropical Diseases, v. 11, n. 6 JUN 2017. Web of Science Citations: 28.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.