| Grant number: | 16/09999-9 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | August 01, 2016 |
| End date: | November 15, 2020 |
| Field of knowledge: | Biological Sciences - Zoology |
| Principal Investigator: | Taran Grant |
| Grantee: | Adriana Moriguchi Jeckel |
| Host Institution: | Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 12/10000-5 - A multi-disciplinary approach to the study of amphibian diversification, AP.JP |
| Associated scholarship(s): | 18/03577-0 - Mapping of Alkaloids in Dendrobatid Poison Frogs by Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI), BE.EP.DR |
Abstract Several lineages of anurans independently evolved the ability to secrete alkaloid-containing defensive chemicals acquired from their diet. Although many ecological and chemical aspects of dietary alkaloids have been studied in the last decades, very little is known about the sequestration mechanism in poison frogs. Metabolism and modification of compounds occur usually in order to cope with toxicity and facilitate excretion. However, only a few lineages of poison frogs are known to be able to modify alkaloids. Here, we propose to study the distribution and pharmacokinetics of two alkaloids to better understand their movement through the body of two dendrobatoid species, one of which is capable of sequestering alkaloids and the other is not. These experiments will allow us to identify the organs and tissues involved in alkaloid sequestration, modification, and excretion, and determine whether differences in the uptake efficiency of two different classes of alkaloids can be attributed to different anatomical (and possibly physiological) pathways. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |