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Relation between melatonin and Vitamin D serum in breast cancer women and its therapeutics actions in vitro study

Grant number: 15/26274-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): October 11, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Debora Aparecida Pires de Campos Zuccari
Grantee:Victoria Caroline Pagelkopf
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Breast cancer is the neoplasia with major prevalence and mortality in women worldwide, and in 2014, it was estimated 57,120 new cases in Brazil. It has been established the relation between the occurrence of breast cancer and disruption of the circadian cycle, and thereby, vitamin D and melatonin have special importance. The production of melatonin follows a rhythmic pattern dependent on the absence of light, with secretory peak at night, while the production of vitamin D occurs mainly during the day and depend on the UVB spectrum of sun rays. Thus, it is suggested that in situations that lead to changes in the circadian cycle, such as night shifts, melatonin production decreases due to exposure to artificial light by night and consequently there is a decrease in daytime production of vitamin D, because these women sleep during the day and they are less exposed to sunlight. So, we note the importance of research the synergistic action between melatonin and vitamin D in the pathogenesis of breast cancer. Therefore, the aim of this study is to investigate the relationship between serum levels of melatonin and vitamin D in patients with breast cancer and control patients, and to investigate the role of vitamin D and melatonin in the treatment of in vitro cell lines of cancer breast cancer.