Evaluation of adipose tissue microRNA expression regulating neuro-adipose crosstalk in hyperlipidic diet induced obese mice offspring

• Grant number: 16/08202-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): August 01, 2016
• Effective date (End): July 31, 2021
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Alice Cristina Rodrigues
• Grantee: Erica de Sousa
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 18/13793-2 - The role of microRNA-22 in mice metabolic complications due to maternal obesity, BE.EP.DR

Abstract

Obesity has been raised worldwide in an alarming way. It is broadly known that risk factors for obesity are a combination from genetics and environmental. In this context, from studies in animals and human we learned that epigenetics is an important risk factor, becoming clear that maternal metabolic status before and during pregnancy and lactation affects offspring metabolism for their whole lifetime. Among epigenetic mechanisms, microRNAs posttranscriptional regulation of gene expression in adipose tissue has been shown modified by diverse metabolic issues, like excessive weight gain and chronic cold exposure. On the other hand, communication between adipose tissue and nervous system regulates energy expenditure, and is also modified by obesity and cold exposure. However, there are no studies touching directly possible influence of maternal obesity on miRNAs modulating genes related to neuroadipose communication, although this field of research will probably bring highlights concerning metabolic programming. Since obesity is a transgenerational disorder, learning the effects of maternal obesity on offspring neuroadipose communication, which develops influenced by maternal metabolic status, means support future research for therapeutic approaches for obesity and comorbidities. Finally, the aim of this project is evaluating miRNAs expression modified by maternal obesity that can compromise neuroadipose communication, influencing offspring metabolism and capacity for adipose tissue browning.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SOUSA, ERICA; RODRIGUES, ALICE CRISTINA. Maternal Obesity Has Gender-Specific Effects on Mouse Offspring Insulin Sensitivity After beta 3 Adrenergic Agonist Treatment. FASEB JOURNAL, v. 32, n. 1, p. 2-pg., 2018-04-01. (16/08202-0)

DE MENDONCA, MARIANA; ROCHA, KARINA C.; DE SOUSA, ERICA; PEREIRA, BEATRIZ M., V; OYAMA, LILA MISSAE; RODRIGUES, ALICE C.. Aerobic exercise training regulates serum extracellular vesicle miRNAs linked to obesity to promote their beneficial effects in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 319, n. 3, p. 13-pg., 2020-09-01. (18/05426-0, 18/07087-8, 16/08202-0, 17/19513-9)