Obesity has been raised worldwide in an alarming way. It is broadly known that risk factors for obesity are a combination from genetics and environmental. In this context, from studies in animals and human we learned that epigenetics is an important risk factor, becoming clear that maternal metabolic status before and during pregnancy and lactation affects offspring metabolism for their whole lifetime. Among epigenetic mechanisms, microRNAs posttranscriptional regulation of gene expression in adipose tissue has been shown modified by diverse metabolic issues, like excessive weight gain and chronic cold exposure. On the other hand, communication between adipose tissue and nervous system regulates energy expenditure, and is also modified by obesity and cold exposure. However, there are no studies touching directly possible influence of maternal obesity on miRNAs modulating genes related to neuroadipose communication, although this field of research will probably bring highlights concerning metabolic programming. Since obesity is a transgenerational disorder, learning the effects of maternal obesity on offspring neuroadipose communication, which develops influenced by maternal metabolic status, means support future research for therapeutic approaches for obesity and comorbidities. Finally, the aim of this project is evaluating miRNAs expression modified by maternal obesity that can compromise neuroadipose communication, influencing offspring metabolism and capacity for adipose tissue browning.
News published in Agência FAPESP Newsletter about the scholarship: