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Effects of acute administration of Cannabidiol on anxiety and tremors induced by simulation test of public speaking in Parkinson's disease patients

Grant number: 16/06561-2
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2018
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Marcos Hortes Nisihara Chagas
Grantee:Stephanie Martins de Faria
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


Recent studies have pointed to the beneficial effects of cannabidiol (CBD) on anxiety symptoms and possible effects on quality of life of patients with Parkinson's disease (PD), but no study was conducted to evaluate the effects of CBD on anxiety symptoms in PD patients. The aim of this study is to evaluate the effects of acute administration of CBD at a dose of 300mg on tremors and measures of anxiety (subjective and physiological) induced by simulated public speaking in PD patients. The frequency and severity of tremor will be evaluated throughout the experiment by digital three-axis accelerometers. A total of 24 individuals with PD without psychiatric disorders will be allocated to receive CBD 300mg or placebo in a double blind randomized crossover design. The interval between tests should be 15 days. The CBD or placebo will be administered 90 minutes before the beginning the experiment. The results of this project could contribute to greater understanding of the potential effects of CBD on anxiety symptoms and tremors of PD patients and provide data for new clinical drug applications.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FARIA, STEPHANIE MARTINS; FABRICIO, DAIENE DE MORAIS; TUMAS, VITOR; CASTRO, PAULA COSTA; PONTI, MOACIR ANTONELLI; HALLAK, JAIME E. C.; ZUARDI, ANTONIO W.; CRIPPA, JOSE ALEXANDRE S.; NISIHARA CHAGAS, MARCOS HORTES. Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson's disease. JOURNAL OF PSYCHOPHARMACOLOGY, v. 34, n. 2 JAN 2020. Web of Science Citations: 0.
STEPHANIE MARTINS DE FARIA; MADSON ALAN MAXIMIANO-BARRETO; DAIENE DE MORAIS; MARCOS HORTES NISIHARA CHAGAS. Impacto dos sintomas de ansiedade na qualidade de vida na doença de Parkinson: uma revisão sistemática. Jornal Brasileiro de Psiquiatria, v. 68, n. 1, p. 48-55, Mar. 2019.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FARIA, Stephanie Martins de. Effects of acute administration of Cannabidiol on anxiety and tremors induced by simulation test of public speaking in Parkinson\'s disease patients. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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