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Why does not Saccharomyces cerevisiae grow faster on glucose than on sucrose?

Grant number: 16/07285-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2016
Effective date (End): May 31, 2021
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal Investigator:Andreas Karoly Gombert
Grantee:Carla Ines Soares Rodrigues
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):17/18206-5 - Turbo yeast: fast glycolytic rates displayed by sucrose-grown Saccharomyces cerevisiae, BE.EP.DR


Sucrose holds a promising role as an alternative raw material to fossil fuels for goods manufacturing in industrial fields such as chemical and liquid fuels, particularly owing its low cost and high energy content. Sucrose metabolism in Saccharomyces cerevisiae is driven by the enzyme invertase - which is coded by genes of the SUC gene family - that catalyzes the hydrolysis of this disaccharide, allowing for the release of the monomers glucose and fructose. In S. cerevisiae, a glucose repression mechanism leads to a first glucose utilization, the remaining sugars being only metabolized in the absence or low concentrations of this monosaccharide. The yeast S. cerevisiae is currently the most largely employed microorganism in the fermentation industry due to its well-known biochemical features. In spite of these aspects, sucrose metabolism in S. cerevisiae is an underresearched topic and some fundamental questions remain open, such as "Why do S. cerevisiae strains do not grow faster on glucose than on sucrose?". In principle, this should happen, since glucose metabolism is simpler than that of sucrose. Nevertheless, some previous studies on sucrose utilization by S. cerevisiae report higher specific growth rate of this yeast on sucrose, when compared to the growth on glucose. On the one hand, the majority of those studies used strains adapted during many generations, which could compromise the interpretation of results. On the other hand, the precise mechanisms of gene regulation behind sucrose catabolism in Saccharomyces cerevisiae have not yet been explained. This work aims at addressing these issues by providing a quantitative analysis of the physiology of different S. cerevisiae strains on sucrose, as well as an investigation on the levels of expression of possible genes involved in regulation by sucrose.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOARES RODRIGUES, CARLA INES; WAHL, ALJOSCHA; GOMBERT, ANDREAS K.. erobic growth physiology of Saccharomyces cerevisiae on sucrose is strain-dependen. FEMS Yeast Research, v. 21, n. 3, . (17/18206-5, 17/08464-7, 16/07285-9)
RODRIGUES, CARLA INES SOARES; DEN RIDDER, MAXIME; PABST, MARTIN; GOMBERT, ANDREAS K.; WAHL, SEBASTIAN ALJOSCHA. Comparative proteome analysis of different Saccharomyces cerevisiae strains during growth on sucrose and glucose. SCIENTIFIC REPORTS, v. 13, n. 1, p. 10-pg., . (16/07285-9, 17/18206-5, 17/08464-7)
SOARES RODRIGUES, CARLA INES; WAHL, ALJOSCHA; GOMBERT, ANDREAS K.. Aerobic growth physiology of Saccharomyces cerevisiae on sucrose is strain-dependent. FEMS Yeast Research, v. 21, n. 3, p. 13-pg., . (16/07285-9, 17/18206-5, 17/08464-7)

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