Advanced search
Start date

Ischemic acute kidney injury and physical exercise

Grant number: 16/09368-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2019
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Lucia da Conceição Andrade
Grantee:Isabella Peres Zanfra
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The project proposes to study the participation of physical exercise in acute kidney injury (AKI). It is known that physical exercise has fundamental role in chronic kidney disease progression. The question we intend to answer is if practice of exercise would be a protecting factor during renal ischemic insult. The research project will perform physical training in rats, composed by aerobic and strength exercises, during nine weeks. At the end of these nine weeks, the rats will be submitted to bilateral renal hilum clamping, for thirty minutes, followed by reperfusion, in order to induce AKI. The control group will follow the same ischemic process, although they have not been trained - only submitted to light aerobic training, in order to simulate environmental and stress conditions. After AKI has been established, the rats will be assessed on multiple aspects regarding renal function, in order to investigate possible correlations between previous physical exercise and response to AKI. We will analyses glomerular and tubular function, PCNA, apoptosis, klotho and cell cycle.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list using this form.