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Odontoblast-like cell response to calcium aluminate cement

Grant number: 16/11461-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2018
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal researcher:Larissa Moreira Spinola de Castro Raucci
Grantee:Nadyne Saab Messias
Home Institution: Universidade de Ribeirão Preto (UNAERP). Campus Ribeirão Preto. Ribeirão Preto , SP, Brazil

Abstract

Calcium aluminate cement (CAC) was developed at Federal University of São Carlos for endodontic purpose as an alternative to mineral trioxide aggregate cement (MTA). Initial studies showed CAC exhibits better mechanical properties than MTA and promising biological results both in osteoblastic cells in vitro and in bone defects when applied in vivo. However, the effects of CAC on odontoblasts are not known. Considering the potential application of this new biomaterial in pulp regenerative therapies, the aim of this study is to evaluate different aspects of the progression of odontoblast-like cell cultures of MDPC-23 cell line exposed to different preparations of calcium aluminate cement, using MTA as control. The following parameters will be assessed: 1) cell morphology at days 1 and 3; 2) Cell viability at days 1, 3 and 7; 3) alkaline phosphatase activity at days 7 and 10; 4) matrix mineralization at day 14.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NADYNE SAAB MESSIAS; GABRIELA GRISOTE; ANTONIO SECCO MARTORANO; ROGER RODRIGO FERNANDES; IVONE REGINA DE OLIVEIRA; KARINA FITTIPALDI BOMBONATO-PRADO; PAULO TAMBASCO DE OLIVEIRA; LARISSA MOREIRA SPINOLA DE CASTRO-RAUCCI. Impact of calcium aluminate cement with additives on dental pulp-derived cells. Journal of Applied Oral Science, v. 28, p. -, 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.