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Tumor inflammatory profile in women with breast cancer

Grant number: 15/25233-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2016
Effective date (End): August 31, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Fernando Luiz Affonso Fonseca
Grantee:Beatriz Colosso Bramante
Home Institution: Faculdade de Medicina do ABC (FMABC). Organização Social de Saúde. Fundação do ABC. Santo André , SP, Brazil

Abstract

Among all types of cancer, breast cancer is the most common among women (after non-melanoma skin's) in Brazil and worldwide. Relatively rare before age 35, the incidence increases progressively, especially after 50 years. In addition to the incidence, the disease is responsible for leading cause of cancer mortality among women. According to the INCA, in 2015 are expected 57 120 new cases of breast cancer in Brazil, with an estimated risk of 57 cases per 100,000 women.The invasion and metastasis depend on some skills acquired by tumor cells, such as self-sufficiency in growth signals, insensitivity to growth inhibitory signals, limitless replicative potential and angiogenesis.Currently, the evidence are increased that inflammatory response plays an important role in the different stages of tumor development, including initiation, promotion, malignancy, invasion and metastasis, while the defense cells assume protective role against the tumor. In this context, the immune system is an important determinant in the microenvironment. Thus, it is intended to study the expression of genes involved in inflammation in biopsies and peripheral blood of women with breast cancer.