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Oral contraceptives efficacy as adjuvant treatment on chronic pelvic pain in women with pelvic endometriosis: systematic review and meta-analysis

Grant number: 16/09068-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Francisco José Candido dos Reis
Grantee:Ananda Carolina Moraes de Falcone
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The use of oral contraceptives for the adjuvant treatment of women with mild and severe endometriosis and chronic pelvic pain is considered first-line option due to be a cost-effective medical treatment. It has low side-effects and is well tolarated. However the efficacy compared to others treatments has conflicting results. The aim of this study is to collect data and synthesise the actual knowledge through a systematic review and a meta-analysis. The systematic literature search and qualitative review will be performed according to PRISMA guidelines . The systematic search will be conduced with studies identified by searching MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials e LILACS until 2016. The search strategy will include controled vocabulary ( eSH) and key-words (eg. endometriosis, oral contraceptives, laparosopy e surgery) as synonyms and truncation.

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