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Effectiveness of oral appliance in sustained attention and quality of life of pper Airway Resistance Syndrome

Grant number: 16/13540-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2016
Effective date (End): August 31, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Sonia Maria Guimaraes Pereira Togeiro Moura
Grantee:Fernanda Chin Yu Ogasawara Lee
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Introduction: The Upper Airway Resistance Syndrome (UARS) is a sleep disorder characterized by airway resistance to breathing during sleep that leads to arousals and daytime sleepiness. There are few studies about UARS and its treatment is not well established yet. Objectives: To evaluate the sustained attention and reaction time of patients with UARS through the Psychomotor Vigilance Task (PVT), to apply sleepiness questionnaries and the Epworth sleepiness scale and to compare their results before and after treatment with oral appliance or placebo during 6 months. Methods: inclusion group: both gender; Body Mass Index of 35Kg/m2; age 25 to 55; clinical and polysomnographic paramethers of UARS ((AHI d 5/h and RDI > 5/h and/or flow limitaton > 30% total sleep time and daytime sleepiness and/or fatigue. The patients will answer to sleepiness questionnaries and to daytime sleepiness and fatigue evaluation. They will also be submitted to physical exam, otorhinolaryngologic exam, whole-night polysomnography and Multiple Sleep Latency Test (MSLT). During the intevals of MSLT appliance, patients will be submitted to PVT test for 10 minutes.

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