Investigation of the dynamic interactions between eosinophils and dendritic cells in response to the intestinal microbiota

• Grant number: 16/15882-7
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: January 01, 2017
• End date: December 31, 2017
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Niels Olsen Saraiva Câmara
• Grantee: Aline Ignacio Silvestre da Silva
• Supervisor: Kathy D. Mccoy
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of Calgary, Canada
• Associated to the scholarship: 14/09450-1 - Influence of intestinal microbiota in the subtypes dendritic cells activation in acute colitis ulcerative model, BP.DR

Abstract

The incidence of allergic disorders and autoimmune diseases has increased dramatically in Westernized countries. This increase in disease susceptibility is thought to be the result of decreased microbial exposure during early childhood. The commensal microbiota educates the innate and adaptive immune systems to maintain homeostasis and some alterations in microbial composition (also referred to as dysbiosis) are thought to be associated with increased susceptibility to a multitude of diseases. Macrophages and dendritic cells (DC) are central players in regulating immune responses to gut microbiota and instrumental in shaping mucosal immunity. Eosinophils are another intestinal innate cell type that are found in large numbers in the small intestine. An important role for eosinophil and DC/macrophage interactions has therefore been emerging, encouraging future investigations into cooperative eosinophil-DC interaction. In this context the actual project aims to investigate the dynamic interactions between eosinophils and dendritic cells in response to the intestinal microbiota.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MCCOY, KATHY D.; IGNACIO, ALINE; GEUKING, MARKUS B.. Microbiota and Type 2 immune responses. CURRENT OPINION IN IMMUNOLOGY, v. 54, p. 20-27, OCT 2018. (16/15882-7)