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Effects of maternal melatonin deprivation during pregnancy and lactation on the offspring neuroimmune system

Grant number: 16/18941-4
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): December 01, 2016
Effective date (End): November 30, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:José Cipolla Neto
Grantee:Lívia Clemente Motta Teixeira
Supervisor abroad: Paul J Lucassen
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Amsterdam (UvA), Netherlands  
Associated to the scholarship:14/22313-3 - Influence of the absence of maternal melatonin during pregnancy and lactation on neurogenesis and on somatic and sensorimotor development of the offspring., BP.DR

Abstract

Maternal melatonin plays a pivotal role in providing photoperiodic information to the fetus and by that influencing the regulation and timing of internal rhythms of the offspring and their preparation for extrauterine life. Maternal melatonin deprivation (mainly caused by nightwork and shift work) during pregnancy and lactation has negative health consequences for the offspring that continue into adulthood (e.g. altered energy metabolism). My phD results provide evidences maternal melatonin deprivation (hypomelatonin induced by pinealectmy) during gestation and lactation leads to delay in the development of physical signs, neurological reflexes and impaired hippocampus-dependent learning in adult offspring. The restoration of the maternal plasma melatonin rhythm prevents these developmental delays and cognitive disruption. The next step will be to elucidade by which mechanisms this fenomena takes place. Melatonin is multifaceted molecule that plays a role as an endocrine modulator, immunomodulator, direct free radical scavenger and indirect antioxidant. In consequence, its absence might cause long-term effects in the offspring. Nonetheless, little is known about maternal melatonin deprivation on the development of neuroimmune system and adult neurogenesis. We aim to investigate if maternal hypomelatonin could lead to changes in neuroendocrine and neuroimmune pathways that have a role in shaping neuronal development and subsequently altering function and behavior. Particularly focusing on adult neurogenesis, melatonin, glucocorticoids and the activity of neuroimmune cells in the hippocampus.

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VASQUEZ MATSUDA, VICTOR DANIEL; BUSTELO TEJADA, MARTIN; MOTTA-TEIXEIRA, LIVIA CLEMENTE; IKEBARA, JULIANE MIDORI; CARDOSO, DEBORA STERZECK; MACHADO-NILS, ALINE VILAR; LEE, VITOR YONAMINE; DICCINI, ISABELLE; ARRUDA, BRUNA PETRUCELLI; MARTINS, PAMELA PINHEIRO; MORALES DIAS, NATALIA MYUKI; TESSAROTTO, RAFAELLA PINTO; RAEISOSSADATI, REZA; BRUNO, MARTIN; TAKASE, LUIZ FERNANDO; KIHARA, ALEXANDRE HIROAKI; NOGUEIRA, MARIA INES; XAVIER, GILBERTO FERNANDO; TAKADA, SILVIA HONDA. Impact of neonatal anoxia and hypothermic treatment on development and memory of rats. Experimental Neurology, v. 340, JUN 2021. Web of Science Citations: 0.
BATTAGELLO, DANIELLA S.; LORENZON, ALINE R.; DINIZ, GIOVANNE B.; MOTTA-TEIXEIRA, LIVIA C.; KLEIN, MARIANNE O.; FERREIRA, JOZELIA G. P.; ARIAS, CARLOS M.; ADAMANTIDIS, ANTOINE; SITA, V, LUCIANE; CIPOLLA-NETO, JOSE; BEVILACQUA, ESTELA M. A. F.; SAWCHENKO, PAUL E.; BITTENCOURT, JACKSON C. The Rat Mammary Gland as a Novel Site of Expression of Melanin-Concentrating Hormone Receptor 1 mRNA and Its Protein Immunoreactivity. FRONTIERS IN ENDOCRINOLOGY, v. 11, JUL 31 2020. Web of Science Citations: 0.
DINIZ, GIOVANNE B.; BATTAGELLO, DANIELLA S.; KLEIN, MARIANNE O.; BONO, BIANCA S. M.; FERREIRA, JOZELIA G. P.; MOTTA-TEIXEIRA, LIVIA C.; DUARTE, JESSICA C. G.; PRESSE, FRANCOISE; NAHON, JEAN-LOUIS; ADAMANTIDIS, ANTOINE; CHEE, MELISSA J.; SITA, LUCIANE V.; BITTENCOURT, JACKSON C. Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner. Journal of Neuroscience Research, v. 98, n. 10 JUN 2020. Web of Science Citations: 0.
DINIZ, GIOVANNE B.; BATTAGELLO, DANIELLA S.; CHERUBINI, PEDRO M.; REYES-MENDOZA, JULIO D.; LUNA-ILLADES, CESAR; KLEIN, MARIANNE O.; MOTTA-TEIXEIRA, LIVIA C.; SITA, LUCIANE V.; MIRANDA-ANAYA, MANUEL; MORALES, TERESA; BITTENCOURT, JACKSON C. Melanin-concentrating hormone peptidergic system: Comparative morphology between muroid species. JOURNAL OF COMPARATIVE NEUROLOGY, v. 527, n. 18, p. 2973-3001, DEC 15 2019. Web of Science Citations: 2.
COSTA, HELDER C.; DA-SILVA, JOELCIMAR M.; DINIZ, GIOVANNE B.; MOTTA-TEIXEIRA, LIVIA C.; DA-SILVA, RENATA J.; BATTAGELLO, DANIELLA S.; SITA, V, LUCIANE; MACHADO, CARLA DE-MORAES; HORTA-JUNIOR, JOSE A. C.; BITTENCOURT, JACKSON C. Characterisation and origins of melanin-concentrating hormone immunoreactive fibres of the posterior lobe of the pituitary and median eminence during lactation in the Long-Evans rat. Journal of Neuroendocrinology, v. 31, n. 9, SI SEP 2019. Web of Science Citations: 3.
KUMAR, AMRITA JHA; MOTTA-TEIXEIRA, LIVIA CLEMENTE; TAKADA, SILVIA HONDA; YONAMINE-LEE, VITOR; MACHADO-NILS, ALINE VILAR; XAVIER, GILBERTO FERNANDO; NOGUEIRA, MARIA INES. Behavioral, cognitive and histological changes following neonatal anoxia: Male and female rats' differences at adolescent age. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, v. 73, p. 50-58, APR 2019. Web of Science Citations: 1.
UMEOKA, EDUARDO H. L.; ROBINSON, EDWARD J.; TURIMELLA, SADA LAKSHMI; VAN CAMPEN, JOLIEN S.; MOTTA-TEIXEIRA, LIVIA C.; SARABDJITSINGH, R. ANGELA; GARCIA-CAIRASCO, NORBERTO; BRAUN, KEES; DE GRAAN, PIERRE N.; JOELS, MARIAN. Hyperthermia-induced seizures followed by repetitive stress are associated with age-dependent changes in specific aspects of the mouse stress system. Journal of Neuroendocrinology, v. 31, n. 4 APR 2019. Web of Science Citations: 1.
MOTTA-TEIXEIRA, LIVIA CLEMENTE; MACHADO-NILS, ALINE VILAR; BATTAGELLO, DANIELLA SABINO; DINIZ, GIOVANNE BARONI; ANDRADE-SILVA, JESSICA; SILVA JR, SINESIO; MATOS, RAPHAEL AFONSO; DO AMARAL, FERNANDA GASPAR; XAVIER, GILBERTO FERNANDO; BITTENCOURT, JACKSON CIONI; REITER, RUSSEL J.; LUCASSEN, PAUL JOHN; KOROSI, ANIKO; CIPOLLA-NETO, JOSE. The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior. Hormones and Behavior, v. 105, p. 146-156, SEP 2018. Web of Science Citations: 8.

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