| Grant number: | 16/16831-7 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | January 16, 2017 |
| End date: | January 15, 2018 |
| Field of knowledge: | Biological Sciences - Physiology - General Physiology |
| Principal Investigator: | Ivani Credidio Trombetta |
| Grantee: | Felipe Xerez Cepêda Fonseca |
| Supervisor: | John Andrew Taylor |
| Host Institution: | Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Institution abroad: | Harvard University, Boston, United States |
| Associated to the scholarship: | 15/03274-0 - Diet and exercise improves metabolic, inflammatory changes and sympathovagal Balance in Patients with Metabolic Syndrome and Obstructive Sleep Apnea, BP.DR |
Abstract Background. Patients with metabolic syndrome (MetS) frequently have the co-morbid obstructive sleep apnea (OSA). Recent studies have shown that the prevalence of OSA in MetS patients is about 60%. In MetS, the overlap of OSA exacerbates muscle sympathetic nerve activity (MSNA) and impairs sympathovagal balance. However, the mechanisms and its integration are not completely understood. Metabolic and inflammatory alterations can be candidates to explain, at least in part, these impairments. Moreover, it is not known the effect of hypocaloric diet and exercise training (D+ET) on the inflammation markers, on MSNA and on sympathovagal balance in patients with MetS associated or not with OSA.Objectives. We will investigate: 1) Whether the overlap of OSA in MetS has an additive effect on metabolic and inflammatory alterations; 2) The association among these alterations and sympathovagal balance; and 3) The effect of D+ET on MetS risk factors, severity of OSA, and inflammatory and metabolic markers and these association with MSNA and sympathovagal balance in patients with MetS associated or not with OSA. Main Outcomes. In patients with MetS associated or without OSA: 1) Clarify the influence of metabolic and inflammatory alterations over the sympathovagal balance; and 2) The effect of D+TF in decreasing risk factors for MetS, severity of OSA, MSNA, sympathovagal balance, and their possible association with the improvement of metabolic and inflammatory markers, especially in patients with OSA.Proposal. Patients have been recruited and evaluated in Brazil. Up to now, Felipe had evaluated for pre and post intervention, about 80% of total sample size. In short, all data collected from the evaluations (microneurography, beat-by-beat heart rate and blood pressure) will be analyzed in association and under supervision and expertise of Dr. Taylor. | |
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