Melatonin supplementation effect on trans-differentation process from white adipose tissue to brown adipose tissue in obese mice

• Grant number: 16/07638-9
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date until: January 16, 2017
• End date until: January 15, 2018
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Maria Isabel Cardoso Alonso-Vale
• Grantee: Talita da Silva Mendes de Farias Carvalho
• Supervisor: Saverio Cinti
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Institution abroad: Università Politecnica delle Marche (UNIVPM), Italy
• Associated to the scholarship: 15/03554-2 - The effects of melatonin supplementation on the development of obesity in mice, BP.PD

Abstract

Obesity is becoming a global epidemic and is linked to other diseases including hypertension, cardiovascular disease, diabetes and even some types of cancers. The incidence of obesity worldwide is increasing every year, and this is an indication that current and oncoming therapeutic strategies are not yet fully effective. Recent data suggest that adipocyte mitochondria might play an important role in the development of obesity through defects in the regulation of adipocyte differentiation, apoptosis, production of oxygen radicals, efficiency of oxidative phosphorylation and regulation of conversion of white adipocytes into brown-like adipocytes. Melatonin, the major hormone of the pineal gland, also acts as an anti-oxidant and as a regulator of mitochondrial bioenergetic function. Moreover, studies have shown that melatonin is a hormone responsible for ensuring an adequate energy balance, mainly due to the regulation of energy flow, probably through the activation of brown adipose tissue metabolism. Thus, the melatonin has emerged as an important potential therapeutic tool for treating obesity. This study aims to investigate how melatonin supplementation can acts on trans- differentiation process from white adipose tissue to brown adipose through morphological analyses (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MENDES DE FARIAS, TALITA DA SILVA; CRUZ, MAYSA MARIANA; DA CUNHA DE SA, ROBERTA CAVALCANTE; SEVERI, ILENIA; PERUGINI, JESSICA; SENZACQUA, MARTINA; CERUTTI, SUZETE MARIA; GIORDANO, ANTONIO; CINTI, SAVERIO; CARDOSO ALONSO-VALE, MARIA ISABEL. Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice. FRONTIERS IN ENDOCRINOLOGY, v. 10, NOV 5 2019. (18/05485-6, 17/08582-0, 16/07638-9, 15/03554-2)

DA CUNHA DE SA, ROBERTA D. C.; CRUZ, MAYSA M.; DE FARIAS, TALITA M.; DA SILVA, VIVIANE S.; SIMAO, JUSSARA DE JESUS; TELLES, MONICA M.; ALONSO-VALE, MARIA ISABEL C.. Fish oil reverses metabolic syndrome, adipocyte dysfunction, and altered adipokines secretion triggered by high-fat diet-induced obesity. PHYSIOLOGICAL REPORTS, v. 8, n. 4, FEB 2020. (15/03554-2, 16/07638-9, 17/08582-0)

MENDES DE FARIAS, TALITA DA SILVA; DA PAIXAO, REGISLANE INO; CRUZ, MAYSA MARIANA; CAVALCANTE DA CUNHA DE SA, ROBERTA DOURADO; SIMAO, JUSSARA DE JESUS; ANTRACO, VITOR JACO; CARDOSO ALONSO-VALE, MARIA ISABEL. Melatonin Supplementation Attenuates the Pro-Inflammatory Adipokines Expression in Visceral Fat from Obese Mice Induced by A High-Fat Diet. CELLS, v. 8, n. 9, SEP 2019. (15/03554-2, 16/07638-9, 18/05485-6)