Determination of adenosine and differential protein after acute myocardial infartion

• Grant number: 16/19045-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2016
• Effective date (End): October 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Aline Klassen
• Grantee: Lucelia Alcantara Barros
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated research grant: 12/51692-7 - Role of adaptative immunity on the progress of ischemic heart disease after acute myocardial infarction, AP.TEM

Abstract

Cardiovascular disease, such as myocardial infarction has been an interest of metabolomics and proteomics field, manly for better comprehension of pathologic process associated to therapeutic strategies. Metabolic profile and proteins have been altered after administration of drugs, which are involved in cellular signalization. These profiles contribute for comprehension of the pathology evolution and the pharmacokinetic effects of statins and antiplatelet used for infarction treatment. After ticagrelor administration, patients has presented alteration of adenosine concentration. Thus, the focus of this project is develop a methodology of sample preparation and adenosine quantification in blood of infarcted patients after four therapeutic strategies. In addition, the adenosine concentration will be associated to differentials proteins founded in the same sample, to propose metabolic routes, which can be associated to the patients treatment evolution with the therapies evaluated.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CIESLAROVA, ZUZANA; MAGALDI, MARIANA; BARROS, LUCELIA ALCANTARA; DO LAGO, CLAUDIMIR LUCIO; OLIVEIRA, DANIEL ROSSADO; HELFENSTEIN FONSECA, FRANCISCO ANTONIO; IZAR, MARIA CRISTINA; LOPES, ALINE SORIANO; MAGGI TAVARES, MARINA FRANCO; KLASSEN, ALINE. Capillary electrophoresis with dual diode array detection and tandem mass spectrometry to access cardiovascular biomarkers candidates in human urine: Trimethylamine-N-Oxide and L-carnitine. Journal of Chromatography A, v. 1583, p. 136-142, JAN 4 2019. (12/51692-7, 12/06642-1, 17/27059-6, 16/19045-2)