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Effects of concurrent training on muscle satellite cells and myofibrillar protein synthesis

Grant number: 15/19756-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): November 01, 2016
Effective date (End): October 14, 2019
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Carlos Ugrinowitsch
Grantee:Miguel Soares Conceição
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):17/18780-3 - Effects of concurrent training on muscle satellite cells and myofibrillar protein synthesis, BE.EP.PD

Abstract

Can Satellite Cells (SC) and Myofibrilar Protein Synthesis (MPS) explain the lower muscle gains after Concurrent Training (CT) compared to Resistance Training (RT) alonere. Main: to compare muscle fiber hypertrophy, number of SC and myonuclei and the MPS after 16 weeks of CT and RT. Methods: 20 young male subjects will be allocated in one of the following groups: concurrent training (CT, n=10) or resistance training (RT, n=10). The RT group will perform Leg press, leg extension and leg Curl, 5x8-12 maximum repetitions with 90s of rest, 3x per week. The CT group will perform the same RT protocol followed by a running exercise, 5 sprints of 4 min at an intensity of 85% of VO2máx with 3 min of rest between sets. The subjects will undergo for 3 muscle samples, 2 blood samples, 6 salive samples before and after the first and last training session and 1 muscle strength test and maximum oxygen intake test (VO2máx) before and after experimental period. As CS analysis by immunofluorescence were done in my PhD study, thus the main challenge in the present proposal will be determine the colocalization of gene that can activate SC. The rate of MPS by deuterated water (²H2O) is being performed in one study from our lab headed for Prof. Carlos Ugrinowitsch (FAPESP 2014/19594-0) with collaboration of Prof Stuart Phillips from Mac Master University, Canada. Thus, I believe that I have necessary conditions to understand the physiological mechanisms that can clarify why the muscle hypertrophy is smaller after CT compared RT alone. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CONCEICAO, MIGUEL S.; JUNIOR, EDSON M. M.; TELLES, GUILHERME D.; LIBARDI, CLEITON A.; CASTRO, ALEX; ANDRADE, ANDRE L. L.; BRUM, PATRICIA C.; URIAS, URSULA; KURAUTI, MIRIAN AYUMI; COSTA JUNIOR, JOSE MARIA; BOSCHER, ANTONIO CARLOS; CAVAGLIERI, CLAUDIA R.; CAMERA, DONNY M.; CHACON-MIKAHIL, MARA P. T. Augmented Anabolic Responses after 8-wk Cycling with Blood Flow Restriction. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 51, n. 1, p. 84-93, JAN 2019. Web of Science Citations: 2.
CONCEICAO, MIGUEL S.; VECHIN, FELIPE C.; LIXANDRAO, MANOEL; DAMAS, FELIPE; LIBARDI, CLEITON A.; TRICOLI, VALMOR; ROSCHEL, HAMILTON; CAMERA, DONNY; UGRINOWITSCH, CARLOS. Muscle Fiber Hypertrophy and Myonuclei Addition: A Systematic Review and Meta-analysis. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 7, p. 1385-1393, JUL 2018. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.