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Phytochemical study of Mimosa caesalpiniifolia leaves and hypoglycemic evaluation in diabetic mice

Grant number: 16/14418-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2016
Effective date (End): September 30, 2017
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Marcelo José Dias Silva
Grantee:Marco Antonio de Moura Junior
Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil


The use of plants of flora as a source of active ingredients have been shown to be increasingly effective in the search for drugs. However, little has been done to transform the potential development of new products and patents. This proposal of scientific initiation, linked to post-doctoral project "pharmaceutical formulation development containing Mimosa spp extracts." FAPESP, intends to carry out a study with the Mimosa caesalpiniifolia species in order to enable a new source of secondary metabolites of this species. Extract of pharmacological tests of the ethyl acetate fraction and/or compounds isolated from Mimosa caesalpiniifolia will be realized, since in the previous design shown promising results for the development of pesticides with antiflamatory activity, antifungal and anticancer (Silva et al., 2014). The work will be transdisciplinary, with participants from various campus of UNESP (Biosciences Institute in São Vicente, Araraquara Chemistry Institute, Endocrine Pancreas Physiology Laboratory Bauru) and UNIFESP (Biosciences Institute Baixada Santista). A partnership with the University of Cádiz (UCA) of Spain will allow the exchange of methodologies and scientific information, enriching and complementing the objectives of this research project. (AU)

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