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Influence of radiation on color change of binomial enamel / composite restoration

Grant number: 16/16243-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2016
Effective date (End): October 31, 2017
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Alexandra Mussolino de Queiroz
Grantee:Thais Tedeschi dos Santos
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Every year thousands of new cases of head and neck cancer are diagnosed around the world. Radiation therapy constitutes a treatment method widely used for the treatment of this disease can be indicated as primary therapy, adjuvant to surgical treatment and chemotherapy, or as a palliative treatment for inoperable and advanced stages of the disease. However, radiotherapy in the head and neck affect oral functions of the patient under different aspects, often permanently, negatively influencing the quality of life of the same. Furthermore, these patients have poor oral conditions due to their condition and often require extensive restorative treatments. The composite resin restorations are a viable treatment for these patients and widely used in current dentistry. The aesthetic appearance of this material helps to improve the quality of life of these patients already debilitated, both physically and psychologically. The aim of this study is to analyze the influence of radiation on the color change of the tooth binomial / composite restorations, since the literature shows no account of change of color of teeth and after radiotherapy procedure restorative materials in the head and neck. The experimental sample is composed of 40 bovine incisors were divided into 4 groups, which will be restored with composite resin in 2 levels (microhybrid and nanohíbrida) and subjected to two levels of radiation (present and absent). It will be made on each specimen cavity 2 mm deep and 3 mm in diameter which will be subsequently restored by inserting two increments over which is applied immediately after the last insertion, an axial load to compress the filling material, making the standardized thickness and flat surface to proceed with curing of the material. After the preparation of specimens, they are kept in artificial saliva and stored in an oven for 24 hours, when it will be submitted to finishing and polishing. At the end of these procedures, the initial color measurements will be performed. Specimens to be irradiated receive the fraction of dose of 2 Gy / day for 5 consecutive days, until reaching a total dose of 60 Gy, for a total of 30 fractions for 6 weeks. After the radiation, the specimens are kept in artificial saliva at 37ºC for 24 h, when analysis of the final color is performed. Analysis of the quantitative response of color stability will be performed ("E, "L, "a and "b) and surface roughness. The data will be analyzed statistically. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
QUEIROZ, ALEXANDRA M.; CARPIO-BONILLA, CLAUDIA M.; ARNEZ, MAYA F. M.; DOS SANTOS, THAIS T.; PALMA-DIBB, REGINA G.; OLIVEIRA, HARLEY F.; NELSON-FILHO, PAULO; SILVA, LEA A. B.; PAULA-SILVA, FRANCISCO W. G.. Radiotherapy Activates Matrix Metalloproteinases in the Dentinoenamel Junction of Primary Teeth. JOURNAL OF DENTISTRY FOR CHILDREN, v. 87, n. 2, p. 83-89, . (16/16243-8, 10/17611-4)

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