Study of the immune response, colonization and invasion in poultry (Gallus gallus domesticus) by strains of Salmonella Enteritidis and Salmonella typhimurium containing deletions in genes ClpP and FliD

• Grant number: 16/18340-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2017
• End date: January 05, 2020
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Angelo Berchieri Junior
• Grantee: Fernanda de Oliveira Barbosa
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Associated scholarship(s): 18/04883-8 - Study of gene expression in chicken infected with strains of Salmonella enteritidis and Salmonella typhimurium containing deletions in clpP and fliD genes, BE.EP.DR

Abstract

Salmonella Enteritidis (SE) and Salmonella Typhimurium (ST) are among the most frequent serovars found in birds and humans. It has been shown that the presence of the flagellar structure in pathogen induces intestinal inflammation and attenuation of systemic infection in the host. Moreover, the absence of the protein in aflagellated strains induces severe systemic infection resulting in lower intestinal colonization and inflammatory response. Therefore, we propose the construction of SE and ST strains containing many flagella and exporting large amounts of flagellin possibly attenuates the infection. This study aims to evaluate the infection of these mutant strains containing deletions in genes ClpP and FliD, evaluating their behavior in birds for commercial hein layers. Mutants with the corresponding wild strains, SE and ST, will be inoculated in birds for evaluation of pathogenicity.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BARBOSA, Fernanda de Oliveira. Study of immune response, colonization and invasion of chickens (Gallus gallus domesticus) by strains of Salmonella Enteritidis and Salmonella Typhimurium containing delections in the clpp and flid genes. 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.