Bromopyrrole alkaloids from the Cultured Microbiome of the Marine Sponge Tedania brasiliensis

• Grant number: 16/16033-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2017
• End date: September 30, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Jairo Iván Quintana Bulla
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

The sponge associated microbial communities are significantly diverse, abundant and they are source of immense chemical diversity. Marine sponge bromopyrrole alkaloids present diverse and potent biological activities, and have been exclusively isolated from marine sponges. However, brominated pyrroles are also produced in vitro by marine bacteria. The isolation of such metabolites from bacterial culture media raises the question: are brominated pyrrole alkaloids isolated from sponges produced by these animals or by associated microorganisms? The aim of this project is to isolate and identify aerobic bacteria associated with the sponge Tedania brasiliensis, as well as to characterize the chemical profile of culture media produced by bacteria isolated from the sponge, aiming at to identify the eventual producer(s) microorganism(s) of the brominated pyrrole alkaloids previously isolated from T. brasiliensis, and also other secondary metabolites produced in culture.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUEZ, JULIE P. G.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; DE OLIVEIRA, JULIANA MAGALHAES; MORAIS-URANO, RAQUEL P.; BERTONHA, ARIANE F.; BANDEIRA, KARIN F.; BULLA, JAIRO I. Q.; SETTE, LARA D.; FERREIRA, ANTONIO G.; et al. Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica. Journal of Natural Products, v. 83, n. 1, p. 55-65, JAN 2020. (13/23153-7, 16/21341-9, 17/06014-4, 13/50228-8, 16/16033-3)

FREIRE, VITOR F.; SLIVINSKI, JULIANO; QUINTANA-BULLA, JAIRO I.; MORAES, FERNANDO C.; PARADAS, WLADIMIR C.; SALGADO, LEONARDO T.; PEREIRA, RENATO C.; MOURA, RODRIGO L.; AMADO-FILHO, GILBERTO M.; FERREIRA, ANTONIO G.; et al. Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 6, p. 715-719, NOV-DEC 2019. (16/16033-3, 13/50228-8)

BERLINCK, ROBERTO G. S.; CRNKOVIC, CAMILA M.; GUBIANI, JULIANA R.; BERNARDI, DARLON I.; IOCA, LAURA P.; QUINTANA-BULLA, JAIRO I.. The isolation of water-soluble natural products - challenges, strategies and perspectives. NATURAL PRODUCT REPORTS, OCT 2021. (13/50228-8, 16/16033-3, 19/00447-1, 20/11691-8, 16/05133-7, 17/06014-4, 16/21341-9, 18/10742-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BULLA, Jairo Iván Quintana. Microbiological and chemical study of cultivable associated bacteria of the marine sponge Tedania brasiliensis. 2022. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC/BT) São Carlos.