Bromopyrrole alkaloids from the cultured microbiome of the marine sponge Tedania brasiliensis

• Grant number: 16/16033-3
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): March 01, 2017
• Effective date (End): February 28, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Jairo Iván Quintana Bulla
• Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

The sponge associated microbial communities are significantly diverse, abundant and they are source of immense chemical diversity. Marine sponge bromopyrrole alkaloids present diverse and potent biological activities, and have been exclusively isolated from marine sponges. However, brominated pyrroles are also produced in vitro by marine bacteria. The isolation of such metabolites from bacterial culture media raises the question: are brominated pyrrole alkaloids isolated from sponges produced by these animals or by associated microorganisms? The aim of this project is to isolate and identify aerobic bacteria associated with the sponge Tedania brasiliensis, as well as to characterize the chemical profile of culture media produced by bacteria isolated from the sponge, aiming at to identify the eventual producer(s) microorganism(s) of the brominated pyrrole alkaloids previously isolated from T. brasiliensis, and also other secondary metabolites produced in culture.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUEZ, JULIE P. G.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; DE OLIVEIRA, JULIANA MAGALHAES; MORAIS-URANO, RAQUEL P.; BERTONHA, ARIANE F.; BANDEIRA, KARIN F.; BULLA, JAIRO I. Q.; SETTE, LARA D.; FERREIRA, ANTONIO G.; BATISTA, JR., JOAO M.; SILVA, THAYNA DE SOUZA; DOS SANTOS, RAQUEL ALVES; MARTINS, CARLOS H. G.; LIRA, SIMONE P.; DA CUNHA, MARCOS G.; TRIVELLA, DANIELA B. B.; GRAZZIA, NATHALIA; GOMES, NATALIA E. S.; GADELHA, FERNANDA; MIGUEL, DANILO C.; CAUZ, ANA CAROLINA G.; BROCCHI, MARCELO; BERLINCK, ROBERTO G. S. Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica. Journal of Natural Products, v. 83, n. 1, p. 55-65, JAN 2020. Web of Science Citations: 0.

FREIRE, VITOR F.; SLIVINSKI, JULIANO; QUINTANA-BULLA, JAIRO I.; MORAES, FERNANDO C.; PARADAS, WLADIMIR C.; SALGADO, LEONARDO T.; PEREIRA, RENATO C.; MOURA, RODRIGO L.; AMADO-FILHO, GILBERTO M.; FERREIRA, ANTONIO G.; BERLINCK, ROBERTO G. S. Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 6, p. 715-719, NOV-DEC 2019. Web of Science Citations: 0.