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Evaluation of the tumor suppressor role of microRNAs situated at DLK1-DIO3 genomic region in papillary thyroid carcinoma

Grant number: 16/09107-0
Support type:Scholarships in Brazil - Master
Effective date (Start): January 01, 2017
Effective date (End): September 30, 2018
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Murilo Vieira Geraldo
Grantee:Leonardo Augusto Marson
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Papillary thyroid carcinoma (PTC) is the most prevalent histological subtype of thyroid cancer with increasing incidence worldwide. Recently, abnormal expression of microRNAs (miRNA), emerge as potential diagnostic and prognostic tools for PTC. The large scale analysis of miRNA expression of murine model of PTC revealed the down regulation of several miRNAs from DLK1-DIO3 genomic region. This genomic region, mapped at 14q32, harbors coding and non-coding genes, including more than 50 miRNA genes, many of which described as potent tumor suppressor genes. The observation that a set of Temple Syndrome (TS) patients, which bear 14q32 deletion, present increased risk of developing thyroid cancer at young age suggests that DLK1-DIO3 may harbor tumor suppressor genes important for thyroid follicular cell biology. The objective of this study is to evaluate the tumor suppressor activity of the miRNAs from DLK1-DIO3 region in vitro. To address this issue, computational analyses will be performed to select candidate miRNAs involved in the modulation of key pathways and biological processes important for cancer development and progression. Using a panel of thyroid normal and tumor cell lines, the influence of each candidate miRNA on cell proliferation and death, as well as cell migration and invasion will be analyzed. The data generated by this study will contribute with the understanding of the biological role of miRNAs from DLK1-DIO3 region in PTC and open up perspectives for the development of new therapeutic strategies. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARSON, Leonardo Augusto. Evaluation of the tumor supressor role of microRNAs from the DLK1-DIO3 genomic region in papillary thyroid carcinoma. 2018. 73 f. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia.

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