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Burden of cancer attributable to lifestyle risk factors in Brazil

Grant number: 16/21390-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): July 01, 2017
Effective date (End): June 30, 2018
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:José Eluf Neto
Grantee:Leandro Fórnias Machado de Rezende
Supervisor abroad: Edward Giovannucci
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Harvard University, Cambridge, United States  
Associated to the scholarship:14/25614-4 - Physical inactivity and cancer: from evaluation of etiological evidence to public health impact, BP.DR

Abstract

This proposal consists of a research internship at the Harvard T.H. Chan School of Public Health under the supervision of Professor Edward Giovannucci from July 2017 to June 2018. The work plan prioritizes the research project development, which includes knowledge exchange in preventable cases estimates, literature review, statistical analyses, and writing a manuscript. There is also an intention to attend other academic activities, such as courses and seminars, and develop further scientific investigations. The research internship project aim to deepen the analysis on the burden of cancer attributable to physical inactivity in Brazil, the main objective of the doctoral project, contextualized to the other lifestyle risk factors. Therefore, the objective of the current research project is to estimate the burden of cancer attributable to lifestyle risk factors in Brazil. We will gather lifestyle risk factors prevalence (physical inactivity, low fruit and vegetable intake, overweight, alcohol consumption, and tobacco smoking) from the most recent nationally representative health survey conducted in Brazil, Brazilian National Health Survey, 2013. The magnitude of association between lifestyle risk factors and types of cancer will be obtained from literature review. We will revise International Agency for Research on Cancer monographs and handbooks of prevention, World Cancer Research Fund reports, and search Medline, Embase e Web of Science databases to retrieve relative risks. Through this data we will estimate fractions of cancer attributable to lifestyle risk factors considering different counterfactual scenarios based on risk factor elimination (population attributable fractions - PAF) and reduction (potential impact fractions - PIF), individually and combined. Finally, to estimate number of cancer cases that could be avoided by removing/reducing lifestyle risk factors we will apply PAF/PIF estimates to number of cancer cases in Brazil, obtained from Globocan 2012. (AU)

Articles published in Agência FAPESP about the scholarship:
Healthy habits could avoid 27% of cancer cases in Brazil 
Overweight and obesity make up for more than 15,000 cancer cases per year in Brazil 
Articles published in other Midia: (519 total)
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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEE, DONG HOON; MACHADO DE REZENDE, LEANDRO FORNIAS; ELUF-NETO, JOSE; WU, KANA; TABUNG, FRED K.; GIOVANNUCCI, EDWARD L. Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response. International Journal of Cancer, v. 145, n. 2, p. 360-369, JUL 15 2019. Web of Science Citations: 0.
MACHADO DE REZENDE, LEANDRO FORNIAS; LEE, DONG HOON; DA COSTA LOUZADA, MARIA LAURA; SONG, MINGYANG; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Proportion of cancer cases and deaths attributable to lifestyle risk factors in Brazil. CANCER EPIDEMIOLOGY, v. 59, p. 148-157, APR 2019. Web of Science Citations: 0.
LEE, DONG HOON; MACHADO DE REZENDE, LEANDRO FORNIAS; HU, FRANK B.; JEON, JUSTIN Y.; GIOVANNUCCI, EDWARD L. Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis. Diabetes/Metabolism Research and Reviews, v. 35, n. 2 FEB 2019. Web of Science Citations: 0.
MACHADO DE REZENDE, LEANDRO FORNIAS; TOTARO GARCIA, LEANDRO MARTIN; MIELKE, GREGORE IVEN; LEE, DONG HOON; WU, KANA; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Preventable fractions of colon and breast cancers by increasing physical activity in Brazil: perspectives from plausible counterfactual scenarios. CANCER EPIDEMIOLOGY, v. 56, p. 38-45, OCT 2018. Web of Science Citations: 0.
MACHADO DE REZENDE, LEANDRO FORNIAS; REY-LOPEZ, JUAN PABLO; DE SA, THIAGO HERICK; CHARTRES, NICHOLAS; FABBRI, ALICE; POWELL, LAUREN; STAMATAKIS, EMMANUEL; BERO, LISA. Reporting bias in the literature on the associations of health-related behaviors and statins with cardiovascular disease and all-cause mortality. PLOS BIOLOGY, v. 16, n. 6 JUN 2018. Web of Science Citations: 0.
MACHADO DE REZENDE, LEANDRO FORNIAS; ARNOLD, MELINA; RABACOW, FABIANA MALUF; LEVY, RENATA BERTAZZI; CLARO, RAFAEL MOREIRA; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. The increasing burden of cancer attributable to high body mass index in Brazil. CANCER EPIDEMIOLOGY, v. 54, p. 63-70, JUN 2018. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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