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Luminescent polipyridinic Ru(II) complexes: interest to investigate the Tau protein fibril aggregates

Grant number: 16/12710-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2017
Effective date (End): January 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Rose Maria Carlos
Grantee:Yasmin Thaíse Lisbôa da Veiga
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

In this project we intend to prepare and characterize a series of complexes of ruthenium(II) cis-[Ru(phen-L)2(Apy)2]2+ type, containing in the coordination sphere of 1,10-phenanthroline ligands with the substituent 5-methyl and 4,7-diphenyl and aminopyridines and investigate the effect and influence of substituent on the spectroscopic and electrochemical properties of complexes. The planned system presents individual characteristics that can simultaneously act as a diagnosis in the fibrillation process of Tau protein and as a therapeutic target by monitoring the therapeutic response by changes in the luminescent properties of the complex. These characteristics include luminescence in the red region attributed to the metal fragment {Ru(phenL)2}2+ and the role of the aminopyridines in the treatment of neurodegenerative diseases. (AU)