Characterization and analysis of proteins-based nanoparticles with PcClAl and magnetic nanoparticle in association with hydrogel-based biopolymer to be used in the treatment of neurological diseases.

• Grant number: 16/21504-5
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Effective date (Start): February 27, 2017
• Effective date (End): August 26, 2017
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Antonio Claudio Tedesco
• Grantee: Tácila Gabriele Lopes
• Supervisor: Alain Ponton
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Research place: Université Paris Diderot - Paris 7, France
• Associated to the scholarship: 15/09125-6 - Polymeric nanocarriers and photoactive compounds in diagnosis and treatment of neurodegenerative diseases, BP.MS

Abstract

This research project is directly associated with the master's project, entitled "Polymeric nanocarriers and photoactive compounds in diagnosis and treatment of neurodegenerative diseases" under process number FAPESP 2015/09125-6, and will also assist in a complementary way in its conclusion. Over the years, there have been many advances in nanotechnology area for the development of nanodevices that are biodegradable and biocompatible and with high potential in biomedical applications and diagnostics. Ferrofluids are a new generation of drugs composed by smart colloidal dispersions of magnetic Nanoparticles (MNps) suspended in a base fluid Magnetic with rheological properties, which study flow behavior and deformation of the materials subjects the variable mechanics such as force, velocity and deflection. These MNps have theranostic properties (same time it has therapeutic and diagnostic proposal) and show a high specificity in its targeting to the target tissue, when subject the applying an external magnetic field leading a magnetic hyperthermia process. Another property, it can be used as contrast agents, due to high sensitivity for magnetic resonance image. Accordingly, we believed that in consonance with the initial idea of the master's project, this project will open the possibility to study albumin-based nanocarrier associate with MNPs and Phtalocyanine Chloride Aluminum (PcClAl), and their subsequent interaction with hydrogel-based biopolymer system, aiming, in the future, not only in our initial goals as a central nervous system (CNS), but also it will allow many others biomedical application of this material. To studies of theses biomaterial, will be performed characterization and analyses by measuring size distributions and zeta potential, rheological, microscopy and spectrophotometric properties. The developed research will be made at the laboratory of Professor Alain Ponton, at Université Paris Diderot. In summarize this project leaves no doubt to scientific world about the potentiality, relevance and innovation to connect nanotechnology, photoprocess and magnetics properties in the treatment of Neurological diseases, and still it opens the possibility for future long term collaboration project in the same research field.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CASTILHO-FERNANDES, ANDRIELLE; LOPES, TACILA G.; PRIMO, FERNANDO L.; PINTO, MARCELO R.; TEDESCO, ANTONIO C.. Photodynamic process induced by chloro-aluminum phthalocyanine nanoemulsion in glioblastoma. Photodiagnosis and Photodynamic Therapy, v. 19, p. 221-228, SEP 2017. (13/50181-1, 16/21504-5)