Spectroscopy of redox misbalance induced by UVA and vis radiation on XPC fibroblasts and melanocytes

• Grant number: 16/13433-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: February 01, 2017
• End date: January 31, 2019
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Mauricio da Silva Baptista
• Grantee: Jan Caspar Schlothauer
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Protection of human skin against sun exposition is a complex issue that involves ambivalent aspects of the interaction of light with tissues. Both UVA and visible radiationcauses redox misbalance, which leads to damage to organelles and mitochondrial and genomic DNA. Neither the chromophores involved in light absorption in this wavelength region nor thereactive intermediates generated are well known. In this project, we will use cellular modelswith super-expressed natural chromophores or mimetic of these to be internalized byendocytosis in conjunction with time resolved spectroscopy/microscopy equipment to identify the intracellular localization of chromophores and the reactive intermediaries. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, GUSTAVO THALMER M.; THOMAS, SUMA S.; SILVA, CASSIO PACHECO; SCHLOTHAUER, JAN C.; BAPTISTA, MAURICIO S.; FREITAS, ADILSON A.; BOHNE, CORNELIA; QUINA, FRANK H.. Triplet Excited States and Singlet Oxygen Production by Analogs of Red Wine Pyranoanthocyanins. Photochemistry and Photobiology, v. 95, n. 1, p. 176-182, JAN 2019. (16/13433-0, 13/07937-8)