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Role of endogenous preoptic hydrogen sulfide modulating LPS tolerance.

Grant number: 16/09364-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2017
Effective date (End): March 31, 2020
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Luiz Guilherme de Siqueira Branco
Grantee:Bruna Maitan Santos
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):17/21796-9 - "Role of estradiol in thermoregulatory behavior and hyperalgesia in ovariectomized rats", BE.EP.DR


Fever is by definition a regulated increase in body core temperature (Tb) in defense of the organism against pathogens. Immune system-pathogen interaction induces cytokines and prostaglandins release (inflammation mediators) that leads to activation of central regions involved in control of Tb, being anteroventral preoptic region (AVPO) hierarchically the most important region involved in thermoregulation. Systemic lipopolysaccharide (LPS - endotoxin extracted in the outer membrane of G- bacteria) administration in rats is the most used model to induce fever. Repeated LPS administration causes LPS tolerance which can be characterized by a refractory response of immune system to endotoxin, i.e, the absence of fever. The role of gaseous neuromodulators nitric oxide (NO) and carbon monoxide (CO) in LPS tolerance have been reported, but there is no evidence about the putative participation of hydrogen sulfide (H2S - another gaseous neuromodulator). The present project will test the hypothesis that H2S, endogenously produced by AVPO, participate in LPS tolerance.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, BRUNA M.; NASCIMENTO, GLANCE C.; CAPEL, CAMILA P.; BORGES, GABRIELA S.; ROSOLEN, THALES; SABINO, JOAO P. J.; LEITE-PANISSI, CHRISTIE R. A.; BRANCO, LUIZ G. S.. Sex differences and the role of ovarian hormones in site-specific nociception of SHR. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 317, n. 2, p. R223-R231, . (17/03645-3, 16/09364-3, 16/17681-9)
GARATTINI, EMANUELA G.; SANTOS, BRUNA M.; FERRARI, DANIELE P.; CAPEL, CAMILA P.; FRANCESCATO, HELOISA D. C.; COIMBRA, TEREZILA M.; LEITE-PANISSI, CHRISTIE R. A.; BRANCO, LUIZ G. S.; NASCIMENTO, GLAUCE C.. Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 93, p. 90-101, . (15/03053-3, 17/03645-3, 16/09364-3, 16/17681-9)
JESUS, ALINE A.; PASSAGLIA, PATRICIA; SANTOS, BRUNA M.; RODRIGUES-SANTOS, ISABELLE; FLORES, RAFAEL A.; BATALHAO, MARCELO E.; STABILE, ANGELITA M.; CARNIO, EVELIN C.. Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis. Brain Research, v. 1739, . (18/18459-3, 16/09364-3, 14/22477-6, 15/09857-7)
SANTOS, BRUNA M.; FRANCESCATO, HELOISA D. C.; TURCATO, FLAVIA C.; ANTUNES-RODRIGUES, JOSE; COIMBRA, TEREZILA M.; BRANCO, LUIZ G. S.. Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE(2) production. ACTA PHYSIOLOGICA, . (16/09364-3, 16/17681-9)
SANTOS, BRUNA M.; COSTA, LUIS H. A.; ROCHA, MARIA J.; BRANCO, LUIZ G. S.. Central leukotrienes modulate fever tolerance to LPS in rats. Journal of Thermal Biology, v. 84, p. 245-249, . (16/09364-3, 16/17681-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Bruna Maitan. The role of hypothalamic hydrogen sulphide modulating LPS tolerance. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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