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Kinetic studies on cycloaddition reactions (3+2) in the preparation of substituted 1,2,3-triazoles

Grant number: 16/24726-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2017
Effective date (End): January 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Cooperation agreement: GlaxoSmithKline
Principal Investigator:Arlene Gonçalves Corrêa
Grantee:Kelly Cintra Soares
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock, AP.PCPE


The main objective of this work is to perform a comparative and experimentally study of the (3 + 2) cycloaddition reaction involving azide with aldehydes and alkylidene malonitriles. We will explore experimentally some reactions in order to determine certain kinetic parameters (speed laws, velocity constants, isotope studies, among others) that will help us to understand these transformations and their characteristics in more depth. (AU)