Kinetic studies on cycloaddition reactions (3+2) in the preparation of substituted 1,2,3-triazoles

• Grant number: 16/24726-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): February 01, 2017
• Effective date (End): January 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Acordo de Cooperação: GlaxoSmithKline
• Principal Investigator: Arlene Gonçalves Corrêa
• Grantee: Kelly Cintra Soares
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock, AP.PCPE

Abstract

The main objective of this work is to perform a comparative and experimentally study of the (3 + 2) cycloaddition reaction involving azide with aldehydes and alkylidene malonitriles. We will explore experimentally some reactions in order to determine certain kinetic parameters (speed laws, velocity constants, isotope studies, among others) that will help us to understand these transformations and their characteristics in more depth. (AU)