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Effect of dual specificity phosphatases modulation and sensitization to gemcitabine

Grant number: 16/23013-9
Support type:Scholarships in Brazil - Master
Effective date (Start): December 01, 2016
Effective date (End): June 30, 2018
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Vanessa da Silva Silveira
Grantee:Verena Silva Santos
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:15/10694-5 - Dual specificity phosphatases activity on map kinases signaling regulation: impact on pancreatic ductal adenocarcinoma metabolic reprogramming, AP.JP

Abstract

Given the difficulty to find specific drugs which can treat pancreatic ductal adenocarcinoma (PDAC) efficiently, this project aims to identify molecular targets that may sensitize pancreatic cancer cells to gemcitabine. To achieve this goal and provide additional information regarding PDAC biology, this project will investigate the negative feedback mechanisms involved in MAPK signaling activation mediated by Dual-specificity phosphatases (DUSPs). Therefore, it proposes to evaluate whether the modulation of specific DUSPs presents any sensitizing potential against gemcitabine in pancreatic adenocarcinoma cell lines. (AU)