Virtual rehabilitation effects on dopa-resistant motor signs in patients with Parkinson's disease and their correlation with brain metabolism in vivo

• Grant number: 16/10795-9
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): January 01, 2017
• Effective date (End): November 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: André Carvalho Felício
• Grantee: Michelly Arjona Maciel
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

Parkinson's disease (PD) and The Second Most Common Disease neurodegenerative. To TREAT signs Motors of PD medications as levodopa are Very effective. With Disease Progression appear Signs Engines dopa-resistant As gait changes (freezing) and balance (postural instability) that significantly decrease the quality of life of these patients. Conventional and physiotherapy A Intervention CAN que bring obvious benefits, in particular, there Motors Signs dopa treatment-resistant. By Side Other, physiotherapy without the context of Virtual Reality (VR), not only offers hum environment more dynamic and interactive, with engine Learning possibility (feedback), but Also allows develop cognitive aspects que CAN, no set, offer a better platform To TREAT Signs engines dopa-resistant in PD. However, there are no studies que investigated the mechanisms by which VR could improve signs Engines dopa-resistant in PD. In this study, we will perform protocol um RV 2 Patients with PD groups (with and without signs motors dopa-Resistant). Do we intend to 8 weeks of training and evaluate outcomes OS Engines pre and post intervention with PET-MRI techniques with Fluorodeoxyglucose To assess glucose metabolism in striatal regions and extra-striatal. In addition, we will make three-dimensional gait ratings (gait laboratory) pre- and post-intervention and Clinical Information Collection throughout the study. Thus, with this protocol, we intend to test the effectiveness of VR nsa Signs Engines dopa-resistant of Patients with PD and evaluate. (AU)