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Effect of organic compounds and metal from diesel exhaust particle on citotoxicity in culture of human airway epithelium cells

Grant number: 16/20149-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2017
Effective date (End): January 31, 2018
Field of knowledge:Biological Sciences - Pharmacology - Toxicology
Principal researcher:Mariangela Macchione
Grantee:Raquel Labiapari Nunes
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The diesel-powered vehicles contribute significantly to the increase in air pollution, since they have a large percentage of emissions of particulate matter. The DEP (Diesel Exhaust Particulate) as one component of particulate matter from air pollution, may in many cases lead injury of the airway, may induce oxidative stress the cell, causing as cellular events consequences, disruption of mitochondrial function and other damage, which may even lead to cell apoptosis. The purpose of this project is to study the influence of DEP in the cytotoxicity of the respiratory tract areas cells and how it affects the metabolism of mitochondria. This study will utilize DEP collected from buses school and analyzed by techniques for determining concentrations of organic and inorganic material, following the analysis of toxicity and mitochondrial integrity indicator in BEAS-2B cells. (AU)

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