Hydrophilic and bioactive secondary metabolites produced by filamentous fungi

• Grant number: 16/21341-9
• Support type: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): March 01, 2017
• Status: Discontinued
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Darlon Irineu Bernardi
• Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated scholarship(s): 20/11691-8 - Biosynthesis of roussoellatide, a polyketide isolated from the fungus Roussoella sp. DLM-33, BE.EP.DD

Abstract

The diversity of the secondary metabolites produced in culture by microorganisms is significant. These metabolites have been of great interest due to their structural diversity and possibility of sustained production. More than 20,000 substances have been identified from microbial cultures with various biological applications, such as in pharmaceutical, food, cosmetic or agrochemical industries. In this project we propose the isolation of bioactive natural products from aqueous fractions obtained from culture media produced by endophytic filamentous fungi isolated from Anthurium alcatrazensis and A. loefgrenii. Separation techniques will be used for the isolation of water-soluble substances using different adsorption resins. Bioactive metabolites will be identified prior to evaluating a correlation between the chemical structure of substances isolated and identified and the nature of the extractive resin, thereby to propose general methods of extraction of water-soluble metabolites from fermentation media. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUEZ, JULIE P. G.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; DE OLIVEIRA, JULIANA MAGALHAES; MORAIS-URANO, RAQUEL P.; BERTONHA, ARIANE F.; BANDEIRA, KARIN F.; BULLA, JAIRO I. Q.; SETTE, LARA D.; FERREIRA, ANTONIO G.; BATISTA, JR., JOAO M.; SILVA, THAYNA DE SOUZA; DOS SANTOS, RAQUEL ALVES; MARTINS, CARLOS H. G.; LIRA, SIMONE P.; DA CUNHA, MARCOS G.; TRIVELLA, DANIELA B. B.; GRAZZIA, NATHALIA; GOMES, NATALIA E. S.; GADELHA, FERNANDA; MIGUEL, DANILO C.; CAUZ, ANA CAROLINA G.; BROCCHI, MARCELO; BERLINCK, ROBERTO G. S. Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica. Journal of Natural Products, v. 83, n. 1, p. 55-65, JAN 2020. Web of Science Citations: 0.

BERLINCK, ROBERTO G. S.; MONTEIRO, AFIF F.; BERTONHA, ARIANE F.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; SLIVINSKI, JULIANO; MICHALISKI, LAMONIELLI F.; TONON, LUCIANE A. C.; VENANCIO, VICTOR A.; FREIRE, VITOR F. Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products. NATURAL PRODUCT REPORTS, v. 36, n. 7, p. 981-1004, JUL 1 2019. Web of Science Citations: 2.