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Hydrophilic and bioactive secondary metabolites produced by filamentous fungi

Grant number: 16/21341-9
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2017
Effective date (End): February 28, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Roberto Gomes de Souza Berlinck
Grantee:Darlon Irineu Bernardi
Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):20/11691-8 - Biosynthesis of roussoellatide, a polyketide isolated from the fungus Roussoella sp. DLM-33, BE.EP.DD

Abstract

The diversity of the secondary metabolites produced in culture by microorganisms is significant. These metabolites have been of great interest due to their structural diversity and possibility of sustained production. More than 20,000 substances have been identified from microbial cultures with various biological applications, such as in pharmaceutical, food, cosmetic or agrochemical industries. In this project we propose the isolation of bioactive natural products from aqueous fractions obtained from culture media produced by endophytic filamentous fungi isolated from Anthurium alcatrazensis and A. loefgrenii. Separation techniques will be used for the isolation of water-soluble substances using different adsorption resins. Bioactive metabolites will be identified prior to evaluating a correlation between the chemical structure of substances isolated and identified and the nature of the extractive resin, thereby to propose general methods of extraction of water-soluble metabolites from fermentation media. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERLINCK, ROBERTO G. S.; CRNKOVIC, CAMILA M.; GUBIANI, JULIANA R.; BERNARDI, DARLON I.; IOCA, LAURA P.; QUINTANA-BULLA, JAIRO I.. The isolation of water-soluble natural products - challenges, strategies and perspectives. NATURAL PRODUCT REPORTS, . (13/50228-8, 16/16033-3, 19/00447-1, 20/11691-8, 16/05133-7, 17/06014-4, 16/21341-9, 18/10742-8)
TONON, LUCIANE A. CHIMETTO; RUA, CINTIA; CRNKOVIC, CAMILA M.; BERNARDI, I, DARLON; JUNIOR, OSMINDO R. PIRES; HADDAD, CELIO F. B.; PEDROSA, CAROLINADA S. G.; SOUZA, LETICIA R. Q.; REHEN, STEVENS K.; DE AZEVEDO, GUSTAVO P. R.; et al. Microbiome associated with the tetrodotoxin-bearing anuran Brachycephalus pitanga. Toxicon, v. 203, p. 139-146, . (13/50741-7, 16/14375-4, 16/05133-7, 17/06014-4, 13/50228-8, 16/21341-9, 19/00447-1)
RODRIGUEZ, JULIE P. G.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; DE OLIVEIRA, JULIANA MAGALHAES; MORAIS-URANO, RAQUEL P.; BERTONHA, ARIANE F.; BANDEIRA, KARIN F.; BULLA, JAIRO I. Q.; SETTE, LARA D.; FERREIRA, ANTONIO G.; et al. Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica. Journal of Natural Products, v. 83, n. 1, p. 55-65, . (13/23153-7, 16/21341-9, 17/06014-4, 13/50228-8, 16/16033-3)
KAHLERT, LUKAS; BERNARDI, DARLON; HAUSER, MAURICE; IOCA, LAURA P.; BERLINCK, ROBERTO G. S.; SKELLAM, ELIZABETH J.; COX, RUSSELL J.. Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products. CHEMISTRY-A EUROPEAN JOURNAL, v. 27, n. 46, p. 11895-11903, . (16/05133-7, 18/10742-8, 16/21341-9, 13/50228-8, 20/11691-8, 19/17721-9)
BERLINCK, ROBERTO G. S.; MONTEIRO, AFIF F.; BERTONHA, ARIANE F.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; SLIVINSKI, JULIANO; MICHALISKI, LAMONIELLI F.; TONON, LUCIANE A. C.; VENANCIO, VICTOR A.; FREIRE, VITOR F.. Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products. NATURAL PRODUCT REPORTS, v. 36, n. 7, p. 981-1004, . (16/21341-9, 17/06014-4, 16/14375-4, 16/11949-0, 13/50228-8, 17/25100-9)
KAHLERT, LUKAS; BERNARDI, DARLON; HAUSER, MAURICE; IOCA, LAURA P.; BERLINCK, ROBERTO G. S.; SKELLAM, ELIZABETH J.; COX, RUSSELL J.. Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products. CHEMISTRY-A EUROPEAN JOURNAL, . (19/17721-9, 18/10742-8, 16/05133-7, 16/21341-9, 13/50228-8, 20/11691-8)
BERLINCK, ROBERTO G. S.; BERNARDI, I, DARLON; FILL, TAICIA; FERNANDES, ALESSANDRA A. G.; JURBERG, IGOR D.. The chemistry and biology of guanidine secondary metabolites. NATURAL PRODUCT REPORTS, v. 38, n. 3, p. 586-667, . (13/50228-8, 19/06359-7, 19/01235-8, 16/21341-9, 17/22164-6)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.