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Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characterization, associations with the disease and effects of breaks in sedentary time

Grant number: 16/23319-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2017
Effective date (End): March 31, 2020
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Hamilton Augusto Roschel da Silva
Grantee:Tiago Peçanha de Oliveira
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):19/07150-4 - Breaking up sedentary time in rheumatoid arthritis: effects on vascular function, BE.EP.PD


This postdoctoral is a joint venture between the candidate's PhD research line (FAPESP 2013/05519-4) - i.e. the study of the effects of exercise in the cardiovascular autonomic function in cardiovascular diseases - and the Laboratory of Assessment and Conditioning in Rheumatology of the Rheumatology Division of the General Hospital of the University of Sao Paulo. Since some recent studies have suggested that autonomic dysfunction is an important complication of Rheumatoid Arthritis (RA), and given that a large time in sedentary activities could be a trigger for this dysfunction, in this specific project the student will investigate: (1) the cardiovascular autonomic dysfunction in patients with RA; (2) the relationship between autonomic dysfunction and inflammation and; (3) the effects of breaks in sedentary time in that dysfunction. For this purpose, 30 women with RA will perform: (1) clinical tests; (2) physical activity and fitness assessments; (3) pro-inflammatory cytokines profile and; (4) cardiovascular autonomic assessment. Additionally, 15 healthy women will form a healthy control group (HCG) to perform the cardiovascular autonomic assessment. After the pre-intervention measurements, patients with RA will be divided into 2 groups: 1) breaks in sedentary time (BST) and 2) control group (CG). The intervention period will be of 4 months. During this period, the BST group will be instructed to follow goals aiming to reduce sedentary time. These goals will be composed by 5 categories: leisure, work, transport, social activities and meals; and each goal will have an upgrade at 2 months of intervention. At the end of the intervention period, participants from both groups will perform the same pre-intervention measurements. The Student T test will be performed for comparisons of the cardiovascular autonomic function between healthy and RA women. A mixed model analysis for repeated measurements will be performed to investigate the effects of the intervention in the cardiovascular autonomic function of the BST and CG groups. When pertinent, Tukey post-hoc will be used for multiple comparisons. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PECANHA, TIAGO; RODRIGUES, REYNALDO; PINTO, ANA JESSICA; SA-PINTO, ANA LUCIA; GUEDES, LISSIANE; BONFIGLIOLI, KARINA; GUALANO, BRUNO; ROSCHEL, HAMILTON. Chronotropic Incompetence and Reduced Heart Rate Recovery in Rheumatoid Arthritis. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 24, n. 7, p. 375-380, OCT 2018. Web of Science Citations: 0.
BARTELS, RHENAN; PRODEL, ELIZA; LATERZA, MATEUS C.; DE LIMA, JORGE ROBERTO P.; PECANHA, TIAGO. Heart rate recovery fast-to-slow phase transition: Influence of physical fitness and exercise intensity. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, v. 23, n. 3 MAY 2018. Web of Science Citations: 0.

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