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Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characterization, associations with the disease and effects of breaks in sedentary time

Grant number: 16/23319-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2017
Effective date (End): May 31, 2021
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Hamilton Augusto Roschel da Silva
Grantee:Tiago Peçanha de Oliveira
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):19/07150-4 - Breaking up sedentary time in rheumatoid arthritis: effects on vascular function, BE.EP.PD

Abstract

This postdoctoral is a joint venture between the candidate's PhD research line (FAPESP 2013/05519-4) - i.e. the study of the effects of exercise in the cardiovascular autonomic function in cardiovascular diseases - and the Laboratory of Assessment and Conditioning in Rheumatology of the Rheumatology Division of the General Hospital of the University of Sao Paulo. Since some recent studies have suggested that autonomic dysfunction is an important complication of Rheumatoid Arthritis (RA), and given that a large time in sedentary activities could be a trigger for this dysfunction, in this specific project the student will investigate: (1) the cardiovascular autonomic dysfunction in patients with RA; (2) the relationship between autonomic dysfunction and inflammation and; (3) the effects of breaks in sedentary time in that dysfunction. For this purpose, 30 women with RA will perform: (1) clinical tests; (2) physical activity and fitness assessments; (3) pro-inflammatory cytokines profile and; (4) cardiovascular autonomic assessment. Additionally, 15 healthy women will form a healthy control group (HCG) to perform the cardiovascular autonomic assessment. After the pre-intervention measurements, patients with RA will be divided into 2 groups: 1) breaks in sedentary time (BST) and 2) control group (CG). The intervention period will be of 4 months. During this period, the BST group will be instructed to follow goals aiming to reduce sedentary time. These goals will be composed by 5 categories: leisure, work, transport, social activities and meals; and each goal will have an upgrade at 2 months of intervention. At the end of the intervention period, participants from both groups will perform the same pre-intervention measurements. The Student T test will be performed for comparisons of the cardiovascular autonomic function between healthy and RA women. A mixed model analysis for repeated measurements will be performed to investigate the effects of the intervention in the cardiovascular autonomic function of the BST and CG groups. When pertinent, Tukey post-hoc will be used for multiple comparisons. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
La actividad física disminuye el riesgo cardiovascular en pacientes con enfermedades reumáticas 
Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas 
Physical activity reduces cardiovascular risk in rheumatic patients 
Articles published in other media outlets (77 total):
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SBT Interior: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (14/Jun/2021)
Beto Ribeiro Repórter: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (16/Jun/2021)
Folha de Itapetininga: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (15/Jun/2021)
Diário do Rio Claro online: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas - Diário do Rio Claro (14/Jun/2021)
Jornal SP Norte: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (14/Jun/2021)
Tudo é Espanto: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (14/Jun/2021)
Expresso Regional: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (14/Jun/2021)
Nosso Goiás: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (14/Jun/2021)
Acontece Agora Online: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (14/Jun/2021)
Portal do Governo do Estado de São Paulo: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
Acontece Botucatu : Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
Ata News: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
Mix Vale: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
Brasil em Folhas online: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
Jornal de Itatiba online: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
Bomba Bomba: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
FEDAP - Fundação de Estudos para o Desenvolvimento da Administração Pública: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
Agência de Notícias – Defesa: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (13/Jun/2021)
Guia Viver Bem: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (10/Jun/2021)
Espaço Ecológico no Ar: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (09/Jun/2021)
Atemporal: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (09/Jun/2021)
Saense: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (09/Jun/2021)
Tech 4 Health: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (09/Jun/2021)
Meio Norte online (Piauí): Atividade física reduz risco cardiovascular a quem possui doença reumática (08/Jun/2021)
Boqnews: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
A Crítica (AM) online: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
Revista Pará: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
Portal de Notícias: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
Novo Cantu Notícias: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
Quimiweb: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
Cuidaí: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
Agora Região: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
GMundo News: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
Revista Nursing online: Atividade física reduz risco cardiovascular em pacientes com doenças reumáticas (08/Jun/2021)
Hébergement Web (França): Revmatoid artritli adamlar üçin mask näme üçin gaty ýadaw bolup biler? (05/May/2021)
Catalunya Vanguardista (Espanha): El ejercicio en las enfermedades reumáticas autoinmunes (04/May/2021)
Santé blog (França): Rhumatismes : Pourquoi il ne faut pas s'arrêter de pratiquer l’exercice (02/May/2021)
Paperblog (França): Rhumatismes : Pourquoi il ne faut pas s'arrêter de pratiquer l’exercice (02/May/2021)
Santé log (França): Rhumatismes: Pourquoi il ne faut pas s'arrêter de pratiquer l’exercice (02/May/2021)
Medindia (Índia): Exercise Reduces Heart Disease Risk in Rheumatic Patients (30/Apr/2021)
Boost my Wellness (Índia): Exercise Reduces Heart Disease Risk in Rheumatic Patients (30/Apr/2021)
Health Medicine Network (EUA): Physical activity reduces cardiovascular risk in rheumatic patients (28/Apr/2021)
Patient Talk: Physical activity reduces cardiovascular risk in rheumatic patients (28/Apr/2021)
Sixty Plus Cycling: Physical activity reduces cardiovascular risk in rheumatic patients (28/Apr/2021)
Rheumatology Academy (EUA): Regular Exercise Improves Vascular Function in Patients with Autoimmune Rheumatic Diseases (28/Apr/2021)
One Sky News: Physical activity reduces cardiovascular risk in rheumatic patients (28/Apr/2021)
Jkwshk.tv (China): 体育锻炼可减少风湿病患者的心血管风险 - La actividad física disminuye el riesgo cardiovascular en pacientes con enfermedades reumáticas (28/Apr/2021)
News Medical (Austrália): Regular exercise improves vascular function in patients with autoimmune rheumatic diseases (27/Apr/2021)
Medical Xpress (Reino Unido): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Bioengineer (Reino Unido): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Science Codex: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Scienmag Science Magazine (Reino Unido): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
InfoSurHoy (EUA): Physical activity reduces cardiovascular risk in rheumatic patients. (27/Apr/2021)
7thSpace: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Medicine World Council: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Giachino Plastic Surgery: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Mirage News (Austrália): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Burada Biliyorum (Turquia): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Health Wellness Journal (EUA): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Mazenz (EUA): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Erwotex.net: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Mundo Sano (México): Personas con enfermedades reumáticas y riesgos cardíacos pueden mejorar con ejercicio (27/Apr/2021)
News O Time (Estados Unidos): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Florida News Times (EUA): Physical activity reduces cardiovascular risk in patients with rheumatism (27/Apr/2021)
LaptrinhX: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
California News Times Today (EUA): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Biotech Asia News (Índia): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Biz News Post (EUA): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
MediExpose (ìndia): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
4State News: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
The Health News Express: Physical exercise reduces cardiovascular threat in rheumatic sufferers (27/Apr/2021)
Honest Columnist (EUA): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Actress News: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Healthy Fit Tips: Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
Detonic: Exercise decreases cardio danger in rheumatic clients (27/Apr/2021)
Super Human Radio (EUA): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)
HFACULTY (Emirados Árabes Unidos): Physical activity reduces cardiovascular risk in rheumatic patients (27/Apr/2021)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PINTO, ANA JESSICA; PECANHA, TIAGO; MEIRELES, KAMILA; BENATTI, FABIANA BRAGA; BONFIGLIOLI, KARINA; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; RODRIGUES PEREIRA, ROSA MARIA; COSTA IRIGOYEN, MARIA CLAUDIA; TURNER, JAMES EDWARD; KIRWAN, JOHN P.; OWEN, NEVILLE; DUNSTAN, DAVID W.; ROSCHEL, HAMILTON; GUALANO, BRUNO. A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study. Trials, v. 21, n. 1 FEB 12 2020. Web of Science Citations: 0.
CRISTINA-OLIVEIRA, MICHELLE; MEIRELES, KAMILA; SPRANGER, MARTY D.; O'LEARY, DONAL S.; ROSCHEL, HAMILTON; PECANHA, TIAGO. Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 318, n. 1, p. H90-H109, JAN 2020. Web of Science Citations: 0.
SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; PECANHA, TIAGO; DOS SANTOS, KAMILA MEIRELES; NUNES REZENDE, DIEGO AUGUSTO; ARAUJO, MARIA EUGENIA; BONFIGLIOLI, KARINA; SCAGLIUSI, FERNANDA BAEZA; BENATTI, FABIANA BRAGA; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; PEREIRA, ROSA MARIA R.; ROSCHEL, HAMILTON; GUALANO, BRUNO; PINTO, ANA JESSICA. Ultra-processed food consumption associates with higher cardiovascular risk in rheumatoid arthritis. CLINICAL RHEUMATOLOGY, v. 39, n. 5 JAN 2020. Web of Science Citations: 1.
PECANHA, TIAGO; RODRIGUES, REYNALDO; PINTO, ANA JESSICA; SA-PINTO, ANA LUCIA; GUEDES, LISSIANE; BONFIGLIOLI, KARINA; GUALANO, BRUNO; ROSCHEL, HAMILTON. Chronotropic Incompetence and Reduced Heart Rate Recovery in Rheumatoid Arthritis. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 24, n. 7, p. 375-380, OCT 2018. Web of Science Citations: 0.
BARTELS, RHENAN; PRODEL, ELIZA; LATERZA, MATEUS C.; DE LIMA, JORGE ROBERTO P.; PECANHA, TIAGO. Heart rate recovery fast-to-slow phase transition: Influence of physical fitness and exercise intensity. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, v. 23, n. 3 MAY 2018. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.