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Vascular and parenchymal lung remodeling of the experimental paracoccidioidomycosis

Grant number: 16/23933-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2017
Effective date (End): March 31, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Alexandre Todorovic Fabro
Grantee:Sabrina Setembre Batah
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The paracoccidioidomycosis is an endemic systemic mycosis in Brazil. Its main current clinical question is the residual pulmonary fibrosis after anti-fungal treatment. The myofibroblastic activation and extracellular matrix deposition are critical processes related to Th17 immune response determinants of architectural distortion and remodeling. Collagen V is the only immunogenic collagen associated with Th17 response in lung diseases. The resulting fibrous thickening of the adventitia can contribute to pulmonary hypertension. Treatment with mesenchymal stem cell is a therapeutic possibility for reversal of lung fibrosis. Our goal is to determine the pattern of parenchymal and vascular remodeling in an experimental model of pulmonary fibrosis induced by two distinct species of paracoccidioidomycosis treated or not with mesenchymal stem cells and their impact on pulmonary hypertension. Future clinical perspective would demonstrate the need for a routine diagnosis for pulmonary hypertension and open new therapeutic options for the reversal of pulmonary fibrosis. (AU)