RIDCs: Research, Innovation and Dissemination Centers

• Grant number: 17/03491-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2017
• End date: January 31, 2018
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: João Santana da Silva
• Grantee: Kiyoshi Ferreira Fukutani
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases, AP.CEPID

Abstract

Inflammatory diseases constitute a complex and heterogeneous group of diseases, being an important cause of morbidity and mortality. In the present project, we intend to develop translational research in the area of inflammatory diseases. In addition, an association with chemical substances with training in molecular modeling and synthesis of molecules of development of new drugs for treatment of diseases. Our project consists of 03 subprojects: 1) infectious inflammatory diseases (Leishmaniasis, Chagas Disease, Paracoccidioidomycosis, Tuberculosis, Sepsis); 2) autoimmune inflammatory diseases (Rheumatoid Arthritis, Lupus, Psoriasis, inflammatory bowel diseases and Pemphigus) and allergic (Asthma); 3) Atherosclerosis. The development of the project to identify new common biological targets for a greater number of inflammatory diseases mentioned above. For this, it can be concluded that the analysis of basic and clinical research is a contribution to the identification of new therapeutic targets common to the diseases studied. Specifically, we aim to: 1) recognize new molecular (genetic, intracellular signaling) and immunological (cellular) mechanisms involved in triggering, maintaining and maintaining diseases; 2) search for possible diagnostic and prognostic biomarkers; 3) identify new biological targets for the development of tools (drugs, antibodies, immunobiological, etc.) for the treatment of diseases; 4) parallel to the experimental models, studies performed with patient samples, which will support the data obtained in the experimental models; 5) we simulate genomic and proteomic analyzes in experimental models and patient samples, which also provide significant evidence, complementing a search for new therapeutic targets. Studies on genetic polymorphism in patients; and 6) to develop (via model and synthesis) new molecules for the treatment of diseases. The synthesized molecules are tested for efficacy of the experimental models and subjected to concept tests in samples obtained from patients. Having therapeutic potential, they will endeavor to register, perform stability tests, pharmacokinetics, preclinical toxicology, and clinical trials that will be applied at HC-FMRP-USP. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BOUZAS, MAIARA L.; OLIVEIRA, JULIANA R.; QUEIROZ, ARTUR; FUKUTANI, KIYOSHI F.; BARRAL, ALDINA; RECTOR, ANNABEL; WOLLANTS, ELKE; KEYAERTSE, ELS; VAN DER GUCHT, WINKE; VAN RANST, MARC; et al. Diagnostic accuracy of digital RNA quantification versus real-time PCR for the detection of respiratory syncytial virus in nasopharyngeal aspirates from children with acute respiratory infection. Journal of Clinical Virology, v. 106, p. 34-40, SEP 2018. (17/03491-6)

FUKUTANI, KIYOSHI FERREIRA; KASPRZYKOWSKI, JOSE IRAHE; PASCHOAL, ALEXANDRE ROSSI; GOMES, MATHEUS DE SOUZA; BARRAL, ALDINA; DE OLIVEIRA, I, CAMILA; PEREIRA RAMOS, PABLO IVAN; LOPO DE QUEIROZ, ARTUR TRANCOSO. Meta-Analysis of Aedes Aegypti Expression Datasets: Comparing Virus Infection and Blood-Fed Transcriptomes to Identify Markers of Virus Presence. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 5, JAN 11 2018. (17/03491-6)

EDUARDO FUKUTANI; MORENO RODRIGUES; JOSÉ IRAHE KASPRZYKOWSKI; CINTIA FIGUEIREDO DE ARAUJO; ALEXANDRE ROSSI PASCHOAL; PABLO IVAN PEREIRA RAMOS; KIYOSHI FERREIRA FUKUTANI; ARTUR TRANCOSO LOPO DE QUEIROZ. Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall. Memórias do Instituto Oswaldo Cruz, v. 113, n. 6, 2018-05-28. (17/03491-6)